News & Views |
Featured
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Review Article |
Immunometabolic rewiring of tubular epithelial cells in kidney disease
The interplay between immunological and metabolic processes is important in a variety of processes. This Review describes how changes in lipid and energy metabolism, driven by receptors of the innate immune system, contribute to the response of tubule epithelial cells to injury and the functional consequences of these intersecting pathways in kidney health and disease.
- Sanne van der Rijt
- , Jaklien C. Leemans
- & Alessandra Tammaro
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Review Article |
Experimental models of acute kidney injury for translational research
This Review summarizes the state of the art of acute kidney injury model development, focusing on the translatability of discoveries using human kidney organoid, zebrafish, rodent and large animal models. The authors recommend a multidisciplinary approach to optimize the development of effective therapies for acute kidney injury.
- Neil A. Hukriede
- , Danielle E. Soranno
- & Mark P. de Caestecker
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Review Article |
Renin cells in homeostasis, regeneration and immune defence mechanisms
Increasing evidence suggests that renin-expressing cells are involved in a range of physiological processes beyond their traditional role in blood pressure regulation. Here, the authors describe the role of these cells in nephrovascular development, regeneration, oxygen sensing, haematopoiesis and immune responses.
- R. Ariel Gomez
- & Maria Luisa S. Sequeira-Lopez
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Review Article |
Modelling diabetic nephropathy in mice
Animal models that faithfully recapitulate human diabetic nephropathy (DN) are needed to study disease pathogenesis, identify drug targets and test new therapies. Here, the authors review progress in developing mouse models of DN, the limitations of current models, and opportunities for future development.
- Kengo Azushima
- , Susan B. Gurley
- & Thomas M. Coffman
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Research Highlight |
Tfcp2l1 drives Notch signalling and epithelial diversity in the collecting duct
- Andrea Aguilar
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Research Highlight |
Kidney-specific deletion of Lkb1 perturbs intracellular metabolism and induces severe renal fibrosis
- Jessica K. Edwards
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Review Article |
The use of lineage tracing to study kidney injury and regeneration
Lineage tracing is a sophisticated technique to track cellsin vivo. Here, Paola Romagnani and colleagues describe how lineage tracing can be used to track the fate of cells involved in renal development, pathophysiological changes and regeneration. The authors discuss considerations in selecting an appropriate reporter, promoter, and activating switch for lineage tracing experiments, and approaches to data interpretation.
- Paola Romagnani
- , Yuval Rinkevich
- & Benjamin Dekel
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Research Highlight |
Pathogenic missense mutations result in defective trafficking of polycystin-1 to cilia
- Jessica K. Edwards
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Correspondence |
Nephrons are generated via a series of committed progenitors
- Paola Romagnani
- , Laura Lasagni
- & Giuseppe Remuzzi
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Correspondence |
The Drosophila nephrocyte has a glomerular filtration system
- Fujian Zhang
- & Xiangmei Chen
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Kidney xenotransplantation edges closer to the clinic
Newly identified parvovirus causes kidney failure in mice
Pax2 keeps nephron progenitors on track
Mechanisms of APOL1-associated renal disease
HIF activation in prevention of diabetic nephropathy