Epigenetics articles within Nature Chemistry

Featured

• Article | 03 August 2020

  CD44 regulates epigenetic plasticity by mediating iron endocytosis

  CD44 is a cell-surface adhesion receptor associated with many biological processes that rely on cellular plasticity. Now, CD44 has been shown to mediate endocytosis of iron-bound hyaluronates. Furthermore, iron catalyses the demethylation of repressive histone marks, thereby unlocking the expression of genes regulating cellular plasticity.

  • Sebastian Müller
  • , Fabien Sindikubwabo
  •  & Raphaël Rodriguez

• News & Views | 29 May 2020

  Exploring epigenetics with chemical tools

  Identifying chromatin modifications and their interactomes is imperative to understand how chromatin functions and is regulated. Now, two new studies report on chemical tools that enable characterization of the biological interactions within native chromatin.

  • Yi Zhang
  •  & Tatiana G. Kutateladze

• Article | 22 October 2018

  5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells

  A series of in vitro and in vivo studies has now shown that 5fC is linked to increased nucleosome occupancy and stability. Moreover, there is evidence that Schiff base formation between histones and 5fC impacts RNA polymerase II transcription activity in mouse embryonic stem cells.

  • Eun-Ang Raiber
  • , Guillem Portella
  •  & Shankar Balasubramanian

• Article | 31 July 2017

  Local epigenetic reprogramming induced by G-quadruplex ligands

  Delayed resolution of G-quadruplexes during replication can induce localized loss of epigenetic information and changes in gene expression. Now, this effect has been used to discover biologically potent G-quadruplex ligands and to demonstrate that G-quadruplex stabilization can induce epigenetic changes that are heritable across cell divisions even after the ligand is removed.

  • Guillaume Guilbaud
  • , Pierre Murat
  •  & Shankar Balasubramanian