Epigenetics and plasticity

Definition

Epigenetics and plasticity is the study of the interaction between epigenetic process, which regulate gene expression without changing the deoxyribonucleic acid sequence, and plasticity (the ability of neurons to change their physiological or structural properties in response to internal or external factors).

Latest Research and Reviews

  • Research | | open

    Alterations in intrinsic plasticity are important in epilepsy. Here the authors show that the epigenetic factor CDYL regulates the gene expression of the voltage gated sodium channel, Nav1.6, which contributes to seizures in a rat model of epilepsy.

    • Yongqing Liu
    • , Shirong Lai
    • , Weining Ma
    • , Wei Ke
    • , Chan Zhang
    • , Shumeng Liu
    • , Yu Zhang
    • , Fei Pei
    • , Shaoyi Li
    • , Ming Yi
    • , Yousheng Shu
    • , Yongfeng Shang
    • , Jing Liang
    •  & Zhuo Huang
  • Research |

    Antipsychotic treatment in patients with schizophrenia often reduces hallucinations and delusions, but cognitive deficits that impair performance of everyday activities may persist or worsen. Our findings reveal a mechanism by which increased NF-κB activity leads to increased HDAC2 levels, impairing synaptic plasticity and memory during prolonged antipsychotic treatment.

    • Daisuke Ibi
    • , Mario de la Fuente Revenga
    • , Nebojsa Kezunovic
    • , Carolina Muguruza
    • , Justin M Saunders
    • , Supriya A Gaitonde
    • , José L Moreno
    • , Maryum K Ijaz
    • , Vishaka Santosh
    • , Alexey Kozlenkov
    • , Terrell Holloway
    • , Jeremy Seto
    • , Aintzane García-Bea
    • , Mitsumasa Kurita
    • , Grace E Mosley
    • , Yan Jiang
    • , Daniel J Christoffel
    • , Luis F Callado
    • , Scott J Russo
    • , Stella Dracheva
    • , Juan F López-Giménez
    • , Yongchao Ge
    • , Carlos R Escalante
    • , J Javier Meana
    • , Schahram Akbarian
    • , George W Huntley
    •  & Javier González-Maeso
    Nature Neuroscience 20, 1247–1259
  • Research | | open

    miR-132/212 has been implicated in ocular dominance plasticity during the critical period. Here the authors show that miR-132/212 regulates the expression of genes involved in visual cortex maturation, and that mice lack miR-132/212 show deficits in binocular matching of orientation preferences, which leads to impaired depth perception.

    • Raffaele Mazziotti
    • , Laura Baroncelli
    • , Nicholas Ceglia
    • , Gabriele Chelini
    • , Grazia Della Sala
    • , Christophe Magnan
    • , Debora Napoli
    • , Elena Putignano
    • , Davide Silingardi
    • , Jonida Tola
    • , Paola Tognini
    • , J. Simon C. Arthur
    • , Pierre Baldi
    •  & Tommaso Pizzorusso
  • Research |

    Su et al. investigated the chromatin accessibility status of neurons in the adult mouse dentate gyrus at different timepoints after activation at the genome-wide level. Their study provides a potential mechanism by which neuronal activity may reshape the epigenetic landscape, thereby dynamically changing transcriptome and neuronal properties over time.

    • Yijing Su
    • , Jaehoon Shin
    • , Chun Zhong
    • , Sabrina Wang
    • , Prith Roychowdhury
    • , Jongseuk Lim
    • , David Kim
    • , Guo-li Ming
    •  & Hongjun Song
    Nature Neuroscience 20, 476–483

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