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Cocaine shapes chromatin landscapes via Tet1

Chronic cocaine exposure induces long-lasting, transcription-dependent changes in neuronal function. A genome-wide sequencing study shows how cocaine changes the epigenome to exert specific, long-lasting effects on neuronal transcription.

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Figure 1: Cocaine-dependent changes in the architecture of the 5hmC landscape are associated with changes in gene expression.

Marina Corral Spence/Nature Publishing Group

References

  1. Feng, J. et al. Nat. Neurosci. 18, 536–544 (2015).

    Article  CAS  Google Scholar 

  2. Lister, R. et al. Science 341, 1237905 (2013).

    Article  Google Scholar 

  3. Kriaucionis, S. & Heintz, N. Science 324, 929–930 (2009).

    Article  CAS  Google Scholar 

  4. Tahiliani, M. et al. Science 324, 930–935 (2009).

    Article  CAS  Google Scholar 

  5. Koh, K.P. et al. Cell Stem Cell 8, 200–213 (2011).

    Article  CAS  Google Scholar 

  6. Ito, S. et al. Nature 466, 1129–1133 (2010).

    Article  CAS  Google Scholar 

  7. Dawlaty, M.M. et al. Dev. Cell 24, 310–323 (2013).

    Article  CAS  Google Scholar 

  8. Szulwach, K.E. et al. Nat. Neurosci. 14, 1607–1616 (2011).

    Article  CAS  Google Scholar 

  9. Rudenko, A. et al. Neuron 79, 1109–1122 (2013).

    Article  CAS  Google Scholar 

  10. Li, X. et al. Proc. Natl. Acad. Sci. USA 111, 7120–7125 (2014).

    Article  CAS  Google Scholar 

  11. Kaas, G.A. et al. Neuron 79, 1086–1093 (2013).

    Article  CAS  Google Scholar 

  12. Wen, L. et al. Genome Biol. 15, R49 (2014).

    Article  Google Scholar 

Download references

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Correspondence to Anne E West.

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West, A. Cocaine shapes chromatin landscapes via Tet1. Nat Neurosci 18, 478–480 (2015). https://doi.org/10.1038/nn.3985

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