Endocrinology articles within Nature Reviews Cardiology

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• Review Article | 16 May 2023

  Cardiovascular risk in diabetes mellitus: epidemiology, assessment and prevention

  Individuals with type 2 diabetes mellitus are at high risk of developing cardiovascular disease (CVD). In the context of type 2 diabetes mellitus, Wong and Sattar discuss established and novel mechanisms of CVD, risk assessment and patient stratification, and strategies to reduce multiple risk factors to prevent CVD.

  • Nathan D. Wong
  •  & Naveed Sattar

• Review Article | 16 March 2023

  Obesity and the risk of cardiometabolic diseases

  In this Review, Lucia and colleagues explain why obesity is an evolutionarily novel condition, summarize the epidemiological evidence for its detrimental cardiometabolic consequences, discuss the major mechanisms involved in the association between obesity and the risk of cardiometabolic diseases, and examine the evidence for potential ‘healthy’ phenotypes associated with obesity.

  • Pedro L. Valenzuela
  • , Pedro Carrera-Bastos
  •  & Alejandro Lucia

• Review Article | 13 June 2022

  Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications

  In this Review, the authors discuss the roles of non-canonical WNT signalling in cardiovascular disease. They provide an overview of non-canonical WNT signalling, describe its links to the pathogenesis of atherosclerosis, heart failure and arrhythmias, and explore the clinical potential of targeting individual components of non-canonical WNT signalling in cardiovascular disease.

  • Ioannis Akoumianakis
  • , Murray Polkinghorne
  •  & Charalambos Antoniades

• Research Highlight | 16 July 2020

  Exercise adaptations to milk confer benefits to offspring

  Maternal exercise during pregnancy confers benefits to offspring, including improvements in glucose metabolism, adiposity and cardiac function, via an oligosaccharide present in breast milk.

  • Shimona Starling

• Review Article | 14 July 2020

  SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control

  SGLT2 inhibitors improve cardiovascular and renal outcomes even in patients without diabetes mellitus. In this Review, Cowie and Fisher describe the additional mechanisms of benefit of SGLT2 inhibitors, unrelated to improved glycaemic control.

  • Martin R. Cowie
  •  & Miles Fisher

• Review Article | 22 May 2020

  Cardiac natriuretic peptides

  The heart is an endocrine organ, producing atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in a regulated manner. In this Review, the authors discuss the physiological regulation and actions of the cardiac natriuretic peptides and their clinical use as powerful diagnostic and prognostic biomarkers of heart disease.

  • Jens P. Goetze
  • , Benoit G. Bruneau
  •  & Adolfo J. de Bold