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Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC
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ACT001 inhibited CD133 transcription by targeting and inducing Olig2 ubiquitination degradation
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Review Article
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Involvement of the pro-oncogenic enzyme fatty acid synthase in the hallmarks of cancer: a promising target in anti-cancer therapies
- Dimitri Vanauberg
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LPA receptor 1 (LPAR1) is a novel interaction partner of Filamin A that promotes Filamin A phosphorylation, MRTF-A transcriptional activity and oncogene-induced senescence
- Andreas Konopa
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Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition
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Analysis of the metabolic proteome of lung adenocarcinomas by reverse-phase protein arrays (RPPA) emphasizes mitochondria as targets for therapy
- Laura Torresano
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Connexin 43 confers chemoresistance through activating PI3K
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Review Article
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Emerging role of G9a in cancer stemness and promises as a therapeutic target
- Joshua R. Haebe
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The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells
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Tripartite motif-containing 3 (TRIM3) enhances ER signaling and confers tamoxifen resistance in breast cancer
- Runyi Ye
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Bruton’s tyrosine kinase (BTK) mediates resistance to EGFR inhibition in non-small-cell lung carcinoma
- Chi-Tai Yeh
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LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers
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A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo
- Yi-Wen Wu
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A drug-repositioning screen using splicing-sensitive fluorescent reporters identifies novel modulators of VEGF-A splicing with anti-angiogenic properties
- Eleanor Star
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Diethyldithiocarbamate-copper complex (CuET) inhibits colorectal cancer progression via miR-16-5p and 15b-5p/ALDH1A3/PKM2 axis-mediated aerobic glycolysis pathway
- Xin Huang
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Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts
- Pawan Noel
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Antileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia
- Godelieve Meunier
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Reduction of SCUBE3 by a new marine-derived asterosaponin leads to arrest of glioma cells in G1/S
- Peng-Cheng Qiu
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Myotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma
- Philip Weidner
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Molecular targeting of renal cell carcinoma by an oral combination
- Andre R. Jordan
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Carbidopa suppresses prostate cancer via aryl hydrocarbon receptor-mediated ubiquitination and degradation of androgen receptor
- Zhiwei Chen
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SOX9 interacts with FOXC1 to activate MYC and regulate CDK7 inhibitor sensitivity in triple-negative breast cancer
- Lin Tang
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Profiling of subcellular EGFR interactome reveals hnRNP A3 modulates nuclear EGFR localization
- Tong-Hong Wang
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Post-transcriptional regulation of BRG1 by FIRΔexon2 in gastric cancer
- Guzhanuer Ailiken
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FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer
- Takuro Hirano
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A novel small-molecule inhibitor of trefoil factor 3 (TFF3) potentiates MEK1/2 inhibition in lung adenocarcinoma
- Mengyi Zhang
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Brief Communication
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CtBP—a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma
- Ayesha T. Chawla
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Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death
- Anne M. van Harten
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CD36 plays a critical role in proliferation, migration and tamoxifen-inhibited growth of ER-positive breast cancer cells
- Yu Liang
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Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma
- Wei Chen
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Depletion of ZBTB38 potentiates the effects of DNA demethylating agents in cancer cells via CDKN1C mRNA up-regulation
- Claire Marchal
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FIBP knockdown attenuates growth and enhances chemotherapy in colorectal cancer via regulating GSK3β-related pathways
- Yan-Feng Huang
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MEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells
- Lin Lin
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CARF enrichment promotes epithelial–mesenchymal transition via Wnt/β-catenin signaling: its clinical relevance and potential as a therapeutic target
- Rajkumar S. Kalra
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Article
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Upregulation of SALL4 by EGFR activation regulates the stemness of CD44-positive lung cancer
- Wenjing Du
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Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype
- Ulrich A. Hirt
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Original Article
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Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ
- A Di Matteo
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Original Article
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Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells
- H-L Huang
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Original Article
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Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions
- S Murai
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Original Article
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Metformin inhibits SUV39H1-mediated migration of prostate cancer cells
- T Yu
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Original Article
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Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells
- S Kumar
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Original Article
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Modification of tumor cell exosome content by transfection with wt-p53 and microRNA-125b expressing plasmid DNA and its effect on macrophage polarization
- M Trivedi
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Original Article
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RETRACTED ARTICLE: A natural food sweetener with anti-pancreatic cancer properties
- C Liu
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- & Y-X Sun
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Original Article
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Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1
- P Torres-Ayuso
- , M Tello-Lafoz
- & A Ávila-Flores
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Original Article
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A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1–MMP
- S A Shiryaev
- , A G Remacle
- & A Y Strongin
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling
Compensatory angiogenesis and tumor refractoriness