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A device that operates within a self-assembled 3D DNA crystal
Although DNA nanotechnology has found many applications in developing functional structures, there has never been an independent device contained within a 3D crystal. Now, a self-assembled three-state device that can change the colour of its crystal by diffusion of DNA-ligated dyes has been reported, representing the potential to develop programmable nanomechanical devices.
- Yudong Hao
- , Martin Kristiansen
- & Nadrian C. Seeman
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An autonomous molecular assembler for programmable chemical synthesis
Molecular machines that assemble polymers in a programmed sequence are fundamental to life. Now, synthetic machinery built from DNA has been used to execute a molecular program that produces peptides, or olefin oligomers, with a defined sequence. The oligomeric product is linked to a double-stranded DNA product that records the sequence of reactions that were executed.
- Wenjing Meng
- , Richard A. Muscat
- & Andrew J. Turberfield
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Conditionally fluorescent molecular probes for detecting single base changes in double-stranded DNA
A molecular probe has been designed that distinguishes double-stranded DNA with single base-pair specificity. In this approach, two destabilizing bubbles, in which the base pairs are mismatched, are generated for each point mutation in the target DNA.
- Sherry Xi Chen
- , David Yu Zhang
- & Georg Seelig
Programmable autonomous synthesis of single-stranded DNA