Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
There is growing interest in biosensors that detect biomarkers in interstitial fluid. This Review provides an overview of recent developments on interstitial fluid biosensors, including device fabrication and sensing mechanisms, and outstanding challenges faced.