Developmental biology articles within Nature Reviews Clinical Oncology

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  • Review Article |

    Cancer stem cells (CSCs) are implicated in cancer development, progression and resistance to treatment; therefore, the signalling pathways that mediate the CSC phenotype are attractive therapeutic targets. In this Review, the authors provide an update on the progress in targeting the Notch, WNT, Hedgehog and Hippo signalling pathways. Additionally, they discuss the interactions of CSCs with the immune system, the roles of CSC-related signalling pathways in immune cells and novel approaches to CSC-directed immunotherapy.

    • Joseph A. Clara
    • , Cecilia Monge
    •  & Naoko Takebe

  • Review Article |

    CRISPR systems have enabled important advances in cancer research by accelerating the development of study models or as a tool in genetic screening studies to discover and validate therapeutic targets. The authors of this Review discuss these applications and new potential uses, such as cancer detection and development of anticancer therapies.

    • Hao Yin
    • , Wen Xue
    •  & Daniel G. Anderson

  • Comment |

    Experimental research on cancer-associated cachexia is advancing at an accelerated pace while knowledge of the complex underlying biology of cachexia in humans lags behind. An unmet need exists to accelerate the identification of causal mechanisms in patients with cancer and to determine the parallels between experimental systems and distinct isotypes of human cachexia.

    • Vickie E. Baracos

  • Comment |

    We posit that disseminating tumour cells detected in the bone marrow or in the circulation are either cancer stem cells with full metastatic potential, tumour-bulk cells, or dormant cancer cells. This model has both therapeutic and diagnostic implications, raising concern over inadequate treatment as well as the possibility of overtreatment resulting from overdiagnosis.

    • Klaus Pantel
    •  & Daniel F. Hayes

  • Review Article |

    Metastatic bone disease in advanced-stage prostate cancer causes some of the most distressing symptoms and is associated with poor survival. This Review discusses the complex pathology of the bone lesion in metastatic prostate cancer and promising therapeutic strategies to treat this disease.

    • Justin Sturge
    • , Matthew P. Caley
    •  & Jonathan Waxman

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