Desmosomes

Definition

Desmosomes are multiprotein complexes that mediate cell-cell adhesion by anchoring intermediate filaments to the plasma membrane. The intercellular adhesive units of desmosomes are the desmoglein and desmocolin members of the cadherin superfamily, which recruit a variety of intracellular proteins to form the intermediate-filament-tethering desmosomal plaque.

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