Dental diseases articles within Nature Communications

Featured

• Article
  28 March 2024 | Open Access

  The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis

  Current animal models of periodontitis are biased towards sample collection from gingival tissue, while other periodontal structures may play similarly important role in the initiation and maintenance of inflammation. Here authors present a model that enables a more comprehensive and longitudinal assessment of periodontal tissues, which points to a pivotal role for the peri-root tissues and an IL-33/ST2 axis in the pathogenesis.

  • Anhao Liu
  • , Mikihito Hayashi
  •  & Tomoki Nakashima

• Article
  29 September 2023 | Open Access

  Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention

  Ferumoxytol (Fer) is an FDA-approved iron oxide formulation that disrupts caries-causing biofilms with high specificity but cannot interfere with enamel acid demineralization. Here, Fer is combined with stannous fluoride (SnF2), resulting in enhanced stability of SnF2 and inhibition of both biofilm accumulation and enamel damage more effectively than either alone.

  • Yue Huang
  • , Yuan Liu
  •  & Hyun Koo

• Article
  11 February 2023 | Open Access

  Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants

  EDA variants are associated with X-linked hypohidrotic dysplasia. Here, the authors report the crystal structure of the human EDA-EDAR complex, reveal the important role of this complex in ectodermal development and uncover the structural mechanism of disease-related mutations in EDA.

  • Kang Yu
  • , Chenhui Huang
  •  & Yiqun Wu

• Article
  09 December 2022 | Open Access

  An umbrella review of the evidence linking oral health and systemic noncommunicable diseases

  Previous studies have supported a potential bidirectional association between oral diseases and systemic noncommunicable diseases (NCDs) Here the authors perform an umbrella review of meta-analyses for the association between oral health and NCDs, and report that 27 NCDs were associated with oral disease, however, the overall strength of evidence was found to be unfavorable and with methodological inconsistencies.

  • João Botelho
  • , Paulo Mascarenhas
  •  & Vanessa Machado

• Article
  31 July 2018 | Open Access

  Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity

  Ferumoxytol is a nanoparticle formulation approved for systemic use to treat iron deficiency. Liu et al. show that topical use of ferumoxytol, in combination with low concentrations of H₂O₂, disrupts intractable oral biofilms and prevents tooth decay in vitro and in an animal model.

  • Yuan Liu
  • , Pratap C. Naha
  •  & Hyun Koo