Dental caries articles within Nature Communications

Featured

• Article
  29 September 2023 | Open Access

  Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention

  Ferumoxytol (Fer) is an FDA-approved iron oxide formulation that disrupts caries-causing biofilms with high specificity but cannot interfere with enamel acid demineralization. Here, Fer is combined with stannous fluoride (SnF2), resulting in enhanced stability of SnF2 and inhibition of both biofilm accumulation and enamel damage more effectively than either alone.

  • Yue Huang
  • , Yuan Liu
  •  & Hyun Koo

• Article
  31 July 2018 | Open Access

  Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity

  Ferumoxytol is a nanoparticle formulation approved for systemic use to treat iron deficiency. Liu et al. show that topical use of ferumoxytol, in combination with low concentrations of H₂O₂, disrupts intractable oral biofilms and prevents tooth decay in vitro and in an animal model.

  • Yuan Liu
  • , Pratap C. Naha
  •  & Hyun Koo