Research Highlight |
Featured
-
-
-
News & Views |
Updated Oxford Classification of IgA nephropathy: a new MEST-C score
The Oxford Classification of IgA nephropathy (IgAN) is the most widely accepted system for assessing histologic findings in IgAN. A new publication refines this classification by adding a crescent score, reassessing the segmental sclerosis score, and contextualizing the clinical relevance of the histologic lesions.
- Glen Markowitz
-
-
-
Review Article |
Development and application of human adult stem or progenitor cell organoids
Human adult stem or progenitor cell organoid cultures have been established for multiple organs and have proved valuable in the basic study of pathophysiology as well as in clinical applications. Such an organoid culture system has not yet, however, been developed for the kidney. Here the authors describe the development and application of the available adult stem or progenitor cell organoid cultures, the challenges and feasibility of developing such a system for the kidney, and the potential kidney-specific applications of organoids.
- Maarten B. Rookmaaker
- , Frans Schutgens
- & Hans Clevers
-
Review Article |
The use of lineage tracing to study kidney injury and regeneration
Lineage tracing is a sophisticated technique to track cellsin vivo. Here, Paola Romagnani and colleagues describe how lineage tracing can be used to track the fate of cells involved in renal development, pathophysiological changes and regeneration. The authors discuss considerations in selecting an appropriate reporter, promoter, and activating switch for lineage tracing experiments, and approaches to data interpretation.
- Paola Romagnani
- , Yuval Rinkevich
- & Benjamin Dekel
-
Review Article |
Diverse origins of the myofibroblast—implications for kidney fibrosis
The persistent production of extracellular matrix during fibrosis leads to impaired organ function. Myofibroblasts are considered the predominant effector cell during fibrosis; however, the exact origin of myofibroblasts during kidney disease is widely debated. Here, the authors describe the evidence supporting the various potential origins of renal myofibroblasts as well as the techniques used to trace and identify these progenitor cells. They discuss the therapeutic methods that might prevent the transition of precursors to a myofibroblast phenotype, thereby inhibiting fibrosis.
- Lucas L. Falke
- , Shima Gholizadeh
- & Tri Q. Nguyen
