Coronary artery disease and stable angina

Definition

Coronary artery disease is a pathological condition in which a coronary artery is narrowed or blocked, usually as a result of atherosclerosis. Stable angina, or 'angina pectoris', is the chest pain or discomfort that can result from the impaired blood flow through the blood vessels in the heart muscle, and usually occurs after exercise or stress.

Latest Research and Reviews

  • Research | | open

    The gut microbiota may play a role in cardiovascular diseases. Here, the authors perform a metagenome-wide association study on stools from individuals with atherosclerotic cardiovascular disease and healthy controls, identifying microbial strains and functions associated with the disease.

    • Zhuye Jie
    • , Huihua Xia
    • , Shi-Long Zhong
    • , Qiang Feng
    • , Shenghui Li
    • , Suisha Liang
    • , Huanzi Zhong
    • , Zhipeng Liu
    • , Yuan Gao
    • , Hui Zhao
    • , Dongya Zhang
    • , Zheng Su
    • , Zhiwei Fang
    • , Zhou Lan
    • , Junhua Li
    • , Liang Xiao
    • , Jun Li
    • , Ruijun Li
    • , Xiaoping Li
    • , Fei Li
    • , Huahui Ren
    • , Yan Huang
    • , Yangqing Peng
    • , Guanglei Li
    • , Bo Wen
    • , Bo Dong
    • , Ji-Yan Chen
    • , Qing-Shan Geng
    • , Zhi-Wei Zhang
    • , Huanming Yang
    • , Jian Wang
    • , Jun Wang
    • , Xuan Zhang
    • , Lise Madsen
    • , Susanne Brix
    • , Guang Ning
    • , Xun Xu
    • , Xin Liu
    • , Yong Hou
    • , Huijue Jia
    • , Kunlun He
    •  & Karsten Kristiansen
  • Reviews | | open

    A range of drugs is available for symptomatic angina, but the optimal choice or combination of therapies is often uncertain, and contemporary guidelines do not necessarily provide definite recommendations. In this Consensus Statement, Ferrari and colleagues propose an individualized approach to angina treatment, which takes into consideration the patient, their comorbidities, and the underlying mechanism of disease.

    • Roberto Ferrari
    • , Paolo G. Camici
    • , Filippo Crea
    • , Nicolas Danchin
    • , Kim Fox
    • , Aldo P. Maggioni
    • , Athanasios J. Manolis
    • , Mario Marzilli
    • , Giuseppe M. C. Rosano
    •  & José L. Lopez-Sendon
  • Research |

    Sekar Kathiresan and colleagues perform a genome-wide association test for coronary artery disease (CAD) using data from the UK Biobank. They identify 15 new loci and perform phenome-wide association scanning, implicating insulin resistance pathways and transendothelial migration of leukocytes in CAD.

    • Derek Klarin
    • , Qiuyu Martin Zhu
    • , Connor A Emdin
    • , Mark Chaffin
    • , Steven Horner
    • , Brian J McMillan
    • , Alison Leed
    • , Michael E Weale
    • , Chris C A Spencer
    • , François Aguet
    • , Ayellet V Segrè
    • , Kristin G Ardlie
    • , Amit V Khera
    • , Virendar K Kaushik
    • , Pradeep Natarajan
    • , CARDIoGRAMplusC4D Consortium
    •  & Sekar Kathiresan
    Nature Genetics 49, 1392–1397

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