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Article |
Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein
Histone H1 binds to nucleosomes with ultrahigh affinity, implying residence times incompatible with efficient biological regulation. Now it has been shown that the disordered regions of H1 retain their large-amplitude dynamics on the nucleosome, which enables a charged disordered histone chaperone to invade the H1–nucleosome complex and vastly accelerate H1 dissociation.
- Pétur O. Heidarsson
- , Davide Mercadante
- & Benjamin Schuler
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Article
| Open AccessInteractions between nascent proteins and the ribosome surface inhibit co-translational folding
During polypeptide biosynthesis, a strong interaction can occur between a segment of an emerged, disordered nascent protein and the ribosomal surface. Now, it has been shown that competition between this ribosomal binding and the folding energetics of an immunoglobulin-like domain modulates the mechanism of co-translational folding.
- Anaïs M. E. Cassaignau
- , Tomasz Włodarski
- & John Christodoulou
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Review Article |
Computational advances in combating colloidal aggregation in drug discovery
Biochemical and cellular assays are often plagued by false positive readouts elicited by nuisance compounds. A significant proportion of those compounds are aggregators. This Review discusses the basis for colloidal aggregation, experimental methods for detecting aggregates and analyses recent progress in computer-based systems for detecting colloidal aggregation with particular emphasis on machine learning [In the online version of this Review originally published, the graphical abstract image was incorrectly credited to ‘Reven T.C. Wurman / Alamy Stock Photo’ this has now been corrected].
- Daniel Reker
- , Gonçalo J. L. Bernardes
- & Tiago Rodrigues