Computational biology and bioinformatics articles within Nature Materials

Featured

  • News & Views |

    Three protein interaction surfaces are computationally designed into one protein subunit to enable their accurate assembly into three-dimensional crystals with user-specified lattice architectures.

    • Eduardo Anaya-Plaza
    •  & Mauri A. Kostiainen

  • Article |

    The process of protein crystallization is poorly understood and difficult to program through the primary sequence. Here the authors develop a computational approach to designing three-dimensional protein crystals with prespecified lattice architectures with high accuracy.

    • Zhe Li
    • , Shunzhi Wang
    •  & David Baker

  • Editorial |

    Machine learning is swiftly infiltrating many areas within the healthcare industry, from diagnosis and prognosis to drug development and epidemiology, with significant potential to transform the medical landscape.

  • Comment |

    This Comment describes some of the common pitfalls encountered in deriving and validating predictive statistical models from high-dimensional data. It offers a fresh perspective on some key statistical issues, providing some guidelines to avoid pitfalls, and to help unfamiliar readers better assess the reliability and significance of their results.

    • Andrew E. Teschendorff

  • News & Views |

    Fragments of DNA that are derived from dead tumour cells and shed into a patient's blood have been utilized as biomarkers for the diagnosis and prognosis of liver cancer.

    • Miljana Tanić
    •  & Stephan Beck

  • News & Views |

    A protein complex found to align with the direction of a magnetic field could be a key piece in the puzzle of how animals detect magnetic fields.

    • Kenneth J. Lohmann

  • News & Views |

    Intrinsically disordered protein polymers can be designed to encode tunable lower or upper critical solution temperatures in physiological solutions.

    • Alex S. Holehouse
    •  & Rohit V. Pappu

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