Clinical epigenetics

Definition

Clinical epigenetics is the application of molecular biology techniques detecting alterations in DNA methylation or histone modification to diagnose or study disorders characterized by heritable defects in the expression of a gene or genome. Applications include Rett syndrome, disorders of imprinting, uniparental inheritance of chromosomes and chromosome segments, and somatic epigenetic anomalies in cancers.

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Latest Research and Reviews

  • Research | | open

    NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

    • Junyi Ju
    • , Aiping Chen
    • , Yexuan Deng
    • , Ming Liu
    • , Ying Wang
    • , Yadong Wang
    • , Min Nie
    • , Chao Wang
    • , Hong Ding
    • , Bing Yao
    • , Tao Gui
    • , Xinyu Li
    • , Zhen Xu
    • , Chi Ma
    • , Yong Song
    • , Marc Kvansakul
    • , Ke Zen
    • , Chen-Yu Zhang
    • , Cheng Luo
    • , Ming Fang
    • , David C. S. Huang
    • , C. David Allis
    • , Renxiang Tan
    • , Changjiang Kathy Zeng
    • , Jiwu Wei
    •  & Quan Zhao
  • Reviews |

    In this Review, Ferrando and López-Otín discuss the role of clonal evolution in leukemia and propose that better understanding of the evolutionary biography of human leukemias and related blood cell malignancies may contribute to improve their clinical management.

    • Adolfo A Ferrando
    •  & Carlos López-Otín
    Nature Medicine 23, 1135–1145
  • Research |

    Analysis of global remethylation in mouse embryos at several developmental stages identifies an epigenetic landscape that partitions extraembryonic tissues within the embryo and resembles a frequent, global departure in genome regulation in human cancers.

    • Zachary D. Smith
    • , Jiantao Shi
    • , Hongcang Gu
    • , Julie Donaghey
    • , Kendell Clement
    • , Davide Cacchiarelli
    • , Andreas Gnirke
    • , Franziska Michor
    •  & Alexander Meissner
    Nature 549, 543–547
  • Research |

    A protocol producing orthotopic patient-derived xenografts at diagnosis, recurrence, and autopsy demonstrates proof of principle for using these tumours for basic and translational research on paediatric solid tumours.

    • Elizabeth Stewart
    • , Sara M. Federico
    • , Xiang Chen
    • , Anang A. Shelat
    • , Cori Bradley
    • , Brittney Gordon
    • , Asa Karlstrom
    • , Nathaniel R. Twarog
    • , Michael R. Clay
    • , Armita Bahrami
    • , Burgess B. Freeman III
    • , Beisi Xu
    • , Xin Zhou
    • , Jianrong Wu
    • , Victoria Honnell
    • , Monica Ocarz
    • , Kaley Blankenship
    • , Jason Dapper
    • , Elaine R. Mardis
    • , Richard K. Wilson
    • , James Downing
    • , Jinghui Zhang
    • , John Easton
    • , Alberto Pappo
    •  & Michael A. Dyer
    Nature 549, 96–100

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