Circadian rhythm signalling peptides and proteins articles within Nature Communications

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  • Article
    | Open Access

    Cryptochromes are important components of biological clocks. Here, the authors uncover that a cryptochrome that enables synchronization of the reproduction of marine worms to the lunar cycle uses an inverse photo-oligomerization mechanism.

    • Hong Ha Vu
    • , Heide Behrmann
    •  & Elmar Behrmann

  • Article
    | Open Access

    Characterizing folding pathways of large proteins that bind complex cofactors is challenging. The authors use optical tweezers to study the 542-residue FAD-binding lightsensor protein dCRY, identifying several intermediates and cofactor binding steps, and dissecting the role of FAD moieties in folding.

    • Sahar Foroutannejad
    • , Lydia L. Good
    •  & Rodrigo A. Maillard

  • Article
    | Open Access

    The molecular mechanisms that define the periodicity or rate of the circadian clock are not well understood. Here the authors use a multidisciplinary approach and identify a mechanism for period regulation that depends on the affinity of the core clock proteins for one another.

    • Clark Rosensweig
    • , Kimberly A. Reynolds
    •  & Carla B. Green

  • Article
    | Open Access

    Food anticipation is thought to be initiated by the central clock in the brain. Here the authors show that the peripheral organs initiate this process by showing that liver-specific deletion of Per2 can inhibit food anticipation by interfering with ß-hydroxybutyrate production and its subsequent processing in the brain.

    • Rohit Chavan
    • , Céline Feillet
    •  & Urs Albrecht

  • Article
    | Open Access

    The cyanobacterial circadian oscillator comprises an autoregulatory loop that is driven by phosphorylation and dephosphorylation of the hexameric kinase KaiC. Kitayama et al.reveal how interactions between KaiC subunits regulate its catalytic activities and ensure robust circadian behaviour.

    • Yohko Kitayama
    • , Taeko Nishiwaki-Ohkawa
    •  & Takao Kondo

  • Article |

    The Caenorhabditis elegans neuropeptide NLP-22 is regulated by a larval circadian clock that is similar to circadian clocks in mammals. Nelson et al. show that NLP-22, expressed in Caenorhabditis elegansRIA interneurons, regulates a sleep-like behavioural quiescence.

    • M.D. Nelson
    • , N.F. Trojanowski
    •  & D.M. Raizen

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