Ciliogenesis

Definition

Ciliogenesis is the process by which cilia – slender outgrowths on a cell's surface in eukaryotes – form. Motile cilia have a beating motion and serve to move fluids, whereas non-motile, or primary, cilia receive signals from other cells or fluids.

Latest Research and Reviews

News and Comment

  • News and Views |

    Primary cilia are cellular structures that have important functions in development and disease. The suppression of multiciliate differentiation of choroid plexus precursors, and maintenance of a single primary cilium by Notch1, is now shown to be involved in choroid plexus tumour formation.

    • Charles Eberhart
    Nature Cell Biology 18, 368–369
  • News and Views |

    The protrusion of cilia into extracellular space provides cells with sensors of localized environmental cues that include fluid flow, mechanical force and important growth factors such as Hedgehog. Live imaging has now captured the initial appearance of cilia during embryogenesis, and defined lineage-specific determinants that restrict extra-embryonal ciliogenesis.

    • Anna S. Nikonova
    •  & Erica A. Golemis
    Nature Cell Biology 17, 109–111
  • News and Views |

    The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors. Kif7 is now found to inhibit microtubule growth to restrict and coordinate the length of axonemal microtubules at the ciliary tip. Such Kif7-mediated organization of the ciliary tip compartment regulates Gli activity and is proposed to be required for correct Hedgehog signalling.

    • Lotte B. Pedersen
    •  & Anna Akhmanova
    Nature Cell Biology 16, 623–625
  • News and Views |

    Centrioles duplicate only once per cell cycle in proliferating cells, whereas in multiciliated cells, hundreds of centrioles form almost simultaneously. The molecular control mechanisms that govern centriole amplification in multiciliated cells are largely unknown. Two studies highlight Deup1 and CCDC78 as key players in this process.

    • Tang K. Tang
    Nature Cell Biology 15, 1400–1402