Chemokines are a class of cytokine protein that act as signalling molecules, regulating immune and inflammatory responses; for example, modulating cell migration properties and localization of target cells such as leucokytes. The biological functions of chemokines are typically mediated by signalling through G protein-coupled chemokine receptors.

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News and Comment

  • Comments and Opinion |

    Numerous exciting studies that advanced our understanding of immune-mediated kidney disease were published in 2018. Whereas most of these studies analysed the role of pro-inflammatory mediators, several novel anti-inflammatory mechanisms were discovered that involve immune cells and mediators with previously unrecognized protective roles in renal disease.

    • Christian Kurts
    •  & Catherine Meyer-Schwesinger
  • News and Views |

    Naive T cells migrate rapidly through the lymph node. A high-resolution look at the chemokine receptor CCR7 and integrin LFA-1 reveals that T cells remain highly responsive to their microenvironment via instantaneous tuning of chemokine-regulated actin flow and integrin-regulated adhesion.

    • Patrick W. Oakes
    •  & Deborah J. Fowell
    Nature Immunology 19, 516-518
  • News and Views |

    Chemokines are important components of the hematopoietic niche. The atypical chemokine receptor 1 (ACKR1), expressed on erythrocyte precursors, regulates myeloid differentiation.

    • Massimo Locati
    • , Alberto Mantovani
    •  & Raffaella Bonecchi
    Nature Immunology 18, 711-712
  • News and Views |

    RIPK3 is a well-known mediator of the necroptosis cell death pathway, which is an important antiviral defence mechanism. In an unexpected twist, RIPK3 has now been shown to also drive neuroprotective inflammation in the central nervous system during West Nile virus infection in a cell-death-independent manner.

    • Katherine B. Ragan
    •  & Jason W. Upton