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Review Article |
Beyond the margins: real-time detection of cancer using targeted fluorophores
Intraoperative fluorescence enables highly specific real-time detection of tumours at the time of surgery. In particular, near-infrared (NIR) fluorescence is a promising tool currently being tested in clinical settings. Zhang et al. discuss the latest developments in NIR fluorophores, cancer-targeting strategies, and detection instrumentation for intraoperative cancer detection, as well as the challenges associated with their effective application in clinical settings.
- Ray R. Zhang
- , Alexandra B. Schroeder
- & Jamey P. Weichert
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Review Article |
Tyrosine kinase inhibitors in chronic myeloid leukaemia: which, when, for whom?
Tyrosine kinase inhibitors (TKIs) are the most common agents used for the treatment of patients with chronic myeloid leukaemia (CML). Several agents are available for frontline treatment, or after the development of resistance or intolerance to agents previously used. Herein, the authors evaluate differences between available TKIs, and discuss several end points that can be considered when selecting the first and subsequent lines of treatment of patients with CML.
- Gianantonio Rosti
- , Fausto Castagnetti
- & Michele Baccarani
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