Chemical genetics articles within Nature Chemistry

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  • Article |

    Polyether ionophores are natural products that display antibacterial activity—but they also show activity against mammalian cells, which has limited their development as clinical antibiotics. Now, a semisynthesis principle of recycling substructures from highly abundant natural polyether ionophores has been used to prepare analogues with enhanced selectivity towards bacterial cells.

    • Shaoquan Lin
    • , Han Liu
    •  & Thomas B. Poulsen

  • Article |

    Delayed resolution of G-quadruplexes during replication can induce localized loss of epigenetic information and changes in gene expression. Now, this effect has been used to discover biologically potent G-quadruplex ligands and to demonstrate that G-quadruplex stabilization can induce epigenetic changes that are heritable across cell divisions even after the ligand is removed.

    • Guillaume Guilbaud
    • , Pierre Murat
    •  & Shankar Balasubramanian

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