Cell death articles within Nature Communications

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  • Article |

    In the early stages of atherosclerosis, macrophages in the vessel wall convert into foam cells, which promote the rise of atherosclerotic plaques. Here Hamada et al. show that the macrophage transcription factor MafB inhibits foam-cell apoptosis, and that its absence promotes atherosclerosis development in mice.

    • Michito Hamada
    • , Megumi Nakamura
    •  & Satoru Takahashi

  • Article |

    Cells in Drosophila salivary glands undergo hormone-dependent apoptosis when larvae pupate. Here, the authors show that the histone methylase dUTX regulates activation of key cell death and autophagy genes leading to the removal of salivary glands during the Drosophilalarval–pupal transition.

    • Donna Denton
    • , May T. Aung-Htut
    •  & Sharad Kumar

  • Article |

    The extent to which damaged and undamaged structures can be segregated within the mitochondrial network during mitophagy is unclear. Abeliovich et al. show that mitochondrial matrix proteins undergo mitophagic degradation at different rates, and that this depends on regulators of mitochondrial dynamics.

    • Hagai Abeliovich
    • , Mostafa Zarei
    •  & Joern Dengjel

  • Article |

    Pellino family proteins are ubiquitin ligases known to regulate immune signalling. Here Yang et al. show that Pellino3 regulates apoptotic TNF signalling by modulating the composition of the death-induced signalling complex, and that absence of Pellino3 sensitizes mice to TNF.

    • Shuo Yang
    • , Bingwei Wang
    •  & Paul N. Moynagh

  • Article |

    Miz1 is a binding partner of the transcription factor c-Myc and a regulator of cell cycle progression. Wolf et al. show that inactivation of Miz1 in the mouse central nervous system results in neurodegeneration, and find that Miz1 is essential for the transcriptional regulation of autophagic flux.

    • Elmar Wolf
    • , Anneli Gebhardt
    •  & Martin Eilers

  • Article
    | Open Access

    Changes in autophagy have been shown to modulate lifespan in lower organisms. Here, Pyo et al.show that mice globally overexpressing the autophagy protein Atg5 live longer and are leaner than normal mice, providing the first evidence that increased autophagy extends lifespan in mammals.

    • Jong-Ok Pyo
    • , Seung-Min Yoo
    •  & Yong-Keun Jung

  • Article |

    Lysosomes are the major degradative compartments within cells, but little is known about cellular mechanisms that control lysosome quality. Here Hung et al.show that lysosomes damaged by light-induced activation of a photosensitizer are selectively ubiquitinated and subsequently eliminated by autophagy.

    • Yu-Hsien Hung
    • , Lily Man-Wen Chen
    •  & Wei Yuan Yang

  • Article |

    Recent studies suggest that there is an overlap between neuronal apoptosis and axon-specific degeneration. Cusack and colleagues show that the caspase-dependent pathways mediating axon degeneration during apoptosis are distinct from those mediating localized axon pruning.

    • Corey L. Cusack
    • , Vijay Swahari
    •  & Mohanish Deshmukh

  • Article
    | Open Access

    Autophagy is a cellular process that controls protein and organelle turnover. Jimenez-Sanchez and colleagues demonstrate in cultured mammalian cells and in fruit fly larvae that autophagy is regulated by Hedgehoc signalling, a pathway that is important for early embryonic development.

    • Maria Jimenez-Sanchez
    • , Fiona M. Menzies
    •  & David C. Rubinsztein

  • Article |

    The protein ataxia-telangiectasia mutated (ATM) detects DNA damage and can trigger cellular apoptosis, but how this process is regulated at the molecular level is unclear. Here, Chunget al. show that the transcription factor FOXO3 controls the formation of ATM-containing signalling complexes at sites of DNA damage that trigger apoptosis.

    • Young Min Chung
    • , See-Hyoung Park
    •  & Mickey C.-T. Hu

  • Article |

    Abnormal mitochondrial fission leads to apoptosis and disease. Li and colleagues reveal the mechanism with which the transcription factor Foxo3a suppresses Fis1-mediated mitochondrial fission and apoptosis in cardiomyocytes and adrenocortical cancer cells, which involves miR-484 inhibition of Fis1 translation.

    • Kun Wang
    • , Bo Long
    •  & Pei-Feng Li

  • Article |

    Soluble cytosolic proteins can be degraded in lysosomes by chaperone-mediated autophagy, however, the current method to measure this process requires isolation of lysosomes. Now, a fluorescent reporter is described that can measure this type of autophagy in intact cells.

    • Hiroshi Koga
    • , Marta Martinez-Vicente
    •  & Ana Maria Cuervo

  • Article
    | Open Access

    The control of cell fate and apoptosis is a continuing challenge in synthetic biology. In this study, systems are developed in which an intracellularly expressed genome-encoded protein simultaneously achieves up- and downregulation of two distinct apoptosis pathways.

    • Hirohide Saito
    • , Yoshihiko Fujita
    •  & Tan Inoue

  • Article |

    Macroautophagy involves remodelling of intracellular membranes, but the role of lipids and lipid enzymes in this process is poorly understood. Here, the authors demonstrate that phospholipase D1, an enzyme that catalyses the production of phosphatidic acid, has a modulatory role in the autophagy process in mammalian cells.

    • Claudia Dall'Armi
    • , Andrés Hurtado-Lorenzo
    •  & Gilbert Di Paolo

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