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Original Article |
Poly(N-isopropylacrylamide)-modified silica beads with hyperbranched polysiloxysilane for three-dimensional cell cultivation
The objective of this study is to establish an immobilization method of PNIPAM on silica beads surface-modified by HBPS, which could be applied to cell cultivation. The PNIPAM-modified silica beads with enough loading of N-isopropylacrylamide (cleaved PNIPAM Mn=14 800 and 23 700) shows controlled cell adhesion and detachment due to lower critical solution temperature behavior of PNIPAM.
- Bo Ra Park
- , Yuta Nabae
- & Masa-aki Kakimoto