Cardiovascular diseases articles within Nature Materials

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    In atherosclerotic plaques, patterns of calcification — which have profound implications for plaque stability and vulnerability to rupture — are determined by the collagen's content and patterning throughout the plaque.

    • Jordan D. Miller

  • Article |

    Analytical techniques reveal that spherical calcium phosphate particles are the first mineralized structures to be formed in the calcification process in cardiovascular tissues. Furthermore, the inner sections of calcified lesions in patients with various cardiovascular diseases are identified as highly crystalline, spherical hydroxyapatite particles that differ in structure from bone mineral.

    • Sergio Bertazzo
    • , Eileen Gentleman
    •  & Molly M. Stevens

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