Featured
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Article
| Open Access
A self-powered intracardiac pacemaker in swine model
Harvesting biomechanical energy from cardiac motion is an attractive power source for implantable bioelectronic devices. Here, the authors report a battery-free, transcatheter, self-powered intracardiac pacemaker for the treatment of arrhythmia in large animal models.
- Zhuo Liu
- , Yiran Hu
- & Zhong Lin Wang
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Article
| Open Access
Injectable hydrogel electrodes as conduction highways to restore native pacing
No preventive treatment addresses the underlying condition that leads to cardiac arrest. Here, researchers developed an injectable hydrogel electrode that achieves pacing that mimics physiological conduction with the potential to eliminate lethal arrhythmias and provide painless defibrillation.
- Gabriel J. Rodriguez-Rivera
- , Allison Post
- & Elizabeth Cosgriff-Hernandez
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Article
| Open Access
Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy
Flexible electronic hydrogels that allow conformal tissue integration, online precision diagnosis, and simultaneous tissue regeneration are desired for advancing the treatment of myocardial infarction. Here, the authors report a chronological adhesive hydrogel patch integrating diagnostic and therapeutic functions through mechanophysiological monitoring and electrocoupling therapy.
- Chaojie Yu
- , Mingyue Shi
- & Junjie Li
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Article
| Open Access
A formal validation of a deep learning-based automated workflow for the interpretation of the echocardiogram
Deep learning can automate the interpretation of medical imaging tests. Here, the authors formally assess the interchangeability of deep learning algorithms with expert human measurements for interpreting echocardiographic studies.
- Jasper Tromp
- , David Bauer
- & Scott D. Solomon
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Article
| Open Access
Self-rechargeable cardiac pacemaker system with triboelectric nanogenerators
Self-powered implantable devices have the potential to extend device operation, though current energy harvesters are both insufficient and inconvenient. Here the authors report on a commercial coin battery-sized high-performance inertia-driven triboelectric nanogenerator based on body motion and gravity that can be used to charge a lithium-ion battery and integrated into a cardiac pacemaker.
- Hanjun Ryu
- , Hyun-moon Park
- & Sang-Woo Kim
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Article
| Open Access
Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction
Many patients, following therapy for acute myocardial infarction, develop adverse cardiac remodelling. Here the authors present injectable recombinant human collagen 10 of 10 type I and III matrices that are able to limit adverse remodelling and improve function of the myocardium.
- Sarah McLaughlin
- , Brian McNeill
- & Emilio I. Alarcon
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Article
| Open Access
Rapid fabrication of reinforced and cell-laden vascular grafts structurally inspired by human coronary arteries
Bioengineering of small diameter vascular grafts that recapitulate the features of native vessels is extremely challenging. Here the authors present a combined dip-spinning and blow-spinning technology to fabricate multi-layered cell-embedded grafts with native mechanical properties.
- Tamara L. Akentjew
- , Claudia Terraza
- & Juan Pablo Acevedo
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Article
| Open Access
Symbiotic cardiac pacemaker
Implantable medical electronic devices are limited by battery lifetime and inflexibility, but self-powered devices can harvest biomechanical energy. Here the authors demonstrate cardiac pacing and correction of sinus arrhythmia with a symbiotic cardiac pacemaker, which is an implanted self-powered pacing system powered by cardiac motion, in a swine.
- Han Ouyang
- , Zhuo Liu
- & Zhou Li
Tissue engineered vascular grafts are resistant to the formation of dystrophic calcification