Research Highlights |
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News & Views |
Skin-cancer stem cells outwitted
Skin-cancer stem cells secrete a factor that organizes a blood-supply system to fuel tumour growth. But the same factor has another sinister function — it stimulates the stem cells to propagate uncontrollably. See Letter p.399
- Salvador Aznar Benitah
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Review Article |
Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
- Jan Paul Medema
- & Louis Vermeulen
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News & Views |
Tumour stem cells switch sides
Tumour stem cells are proposed to be the source of tumour cells. It now emerges that they also give rise to the endothelial cells that line the tumour vasculature, mediating tumour growth and metastasis. See Letters p.824 & p.829
- Victoria L. Bautch
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Letter |
Glioblastoma stem-like cells give rise to tumour endothelium
This is one of two papers showing that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells. The tumour-derived endothelial cells originate in putative glioblastoma-initiating cells and are functionally important for tumorigenesis.
- Rong Wang
- , Kalyani Chadalavada
- & Viviane Tabar
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Letter |
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
This is one of two papers showing that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells. The tumour-derived endothelial cells originate in putative glioblastoma-initiating cells and are functionally important for tumorigenesis.
- Lucia Ricci-Vitiani
- , Roberto Pallini
- & Ruggero De Maria
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Letter |
Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
In this work, the neural crest stem cell marker CD271 is implicated as a cancer stem cell marker, allowing identification and prospective isolation of melanoma cancer stem cells.
- Alexander D. Boiko
- , Olga V. Razorenova
- & Irving L. Weissman
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News & Views |
Invitation to a second round
Tumour cells are non-uniform. The question is whether a distinct subpopulation of the cells drives tumour growth and generates cellular variation. To answer this, the data must be interpreted carefully.
- Peter Dirks