Featured
-
-
Article |
Targeted photoredox catalysis in cancer cells
Current photodynamic therapy photosensitizers require oxygen; however, tumours are often hypoxic. Now, an organoiridium complex with an unusually high redox potential, which is effective in normoxia and hypoxia, has been developed. The organoiridium complex kills cancer cells by an immunogenic apoptotic mechanism involving efficient photocatalytic oxidation of NADH to NAD radicals, and reduction of cytochrome c.
- Huaiyi Huang
- , Samya Banerjee
- & Peter J. Sadler