Calcium and vitamin D articles within Nature Communications

Featured

• Article
  05 October 2023 | Open Access

  Fluorescent sensors for imaging of interstitial calcium

  The study of interstitial calcium remains challenging due to scarce methodology. Here, authors present ultra-low affinity genetically encoded fluorescent biosensors for monitoring calcium in intercellular spaces in living tissues.

  • Ariel A. Valiente-Gabioud
  • , Inés Garteizgogeascoa Suñer
  •  & Oliver Griesbeck

• Article
  13 June 2023 | Open Access

  Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes

  Environmental conditions during pregnancy contribute to offspring metabolic disease. Here, the authors show that immune cells reprogrammed in utero by maternal vitamin D deficiency increase lifetime diabetes risk in the offspring and are sufficient to transplant diabetes.

  • Jisu Oh
  • , Amy E. Riek
  •  & Carlos Bernal-Mizrachi

• Article
  13 June 2023 | Open Access

  Clinical and molecular correlation defines activity of physiological pathways in life-sustaining kidney xenotransplantation

  Porcine kidney xenotransplantation is accelerating towards clinical testing. Here the authors present preclinical results examining xenograft growth and participation in renal endocrine pathways that can be used to inform clinical study design.

  • Daniel J. Firl
  • , Grace Lassiter
  •  & Katherine C. Hall

• Article
  19 April 2022 | Open Access

  Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca²⁺ channel function

  The function of voltage-gated calcium channels in T cells is not well understood and controversial. Here the authors report that a regulatory beta subunit of voltage-gated calcium channels regulates T cell function despite no evidence that these channels were functional within T cells during activation.

  • Serap Erdogmus
  • , Axel R. Concepcion
  •  & Stefan Feske

• Article
  06 August 2021 | Open Access

  Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles

  Nicotinic acid adenine dinucleotide phosphate (NAADP) potent Ca²⁺ mobilizing second messenger which uniquely triggers Ca²⁺ release from acidic endolysosomal organelles. Here the authors identify Lsm12 as an NAADP receptor essential for NAADP-evoked Ca²⁺ release from lysosomes via NAADP binding on its Lsm domain.

  • Jiyuan Zhang
  • , Xin Guan
  •  & Jiusheng Yan

• Article
  07 December 2020 | Open Access

  Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

  Current therapeutic strategies for vitamin D-induced hypercalcemia are poorly efficient. Here the authors identify a new interaction between the vitamin D receptor (VDR) and WBP4 controlling the subcellular localization of VDR and show that ZK168281, a VDR antagonist, enhances the interaction between VDR and WBP4 blunting VDR signalling and normalizing calcium levels in vitamin D-intoxicated mice.

  • Daniela Rovito
  • , Anna Y. Belorusova
  •  & Daniel Metzger

• Article
  02 April 2020 | Open Access

  Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

  Vitamin D is a precursor of the steroid hormone 1,25-dihydroxyvitamin D3, and its deficiency is associated with many adverse health outcomes. Here, Revez et al. perform a genome-wide association study for circulating 25-hydroxyvitamin D in 417,580 individuals and test for potential causal relationships with other traits using Mendelian randomization.

  • Joana A. Revez
  • , Tian Lin
  •  & John J. McGrath

• Article
  15 November 2019 | Open Access

  Genetic variants of calcium and vitamin D metabolism in kidney stone disease

  Kidney stones form in the presence of overabundance of crystal-forming substances such as Ca²⁺ and oxalate. Here, the authors report genome-wide association analyses for kidney stone disease, report seven previously unknown loci and find that some of these loci also associate with Ca²⁺ concentration and excretion.

  • Sarah A. Howles
  • , Akira Wiberg
  •  & Dominic Furniss

• Article
  16 October 2019 | Open Access

  Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

  Elevated inorganic phosphate levels promote excessive parathyroid hormone secretion, which contributes to the aetiology of secondary hyperparathyroidism. Here, the authors show that phosphate directly inhibits the calcium-sensing receptor, the main regulator of parathyroid hormone secretion.

  • Patricia P. Centeno
  • , Amanda Herberger
  •  & Donald T. Ward