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Heparin-network-mediated long-lasting coatings on intravascular catheters for adaptive antithrombosis and antibacterial infection
Catheter-related infection and thrombosis are serious complications, and preventative coatings are not always suitable. Here, the authors report a heparin mediated coating for to address both infections and thrombosis from catheters simultaneously.
- Lin Liu
- , Huan Yu
- & Hengchong Shi
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Article
| Open Access
Nonthermal acceleration of protein hydration by sub-terahertz irradiation
The collective intermolecular dynamics of protein and water molecules, which overlap in subterahertz frequencies, are relevant for protein function expressions. Here the authors develop highly sensitive dielectric measurements, revealing that protein hydration is nonthermally accelerated by sub-terahertz irradiation.
- Jun-ichi Sugiyama
- , Yuji Tokunaga
- & Masahiko Imashimizu
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Article
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Chemical reaction-mediated covalent localization of bacteria
Transplantation of helpful bacteria has been used to treat disease through modulating host microbiota. Here, the authors report a strategy to control bacteria localization in the jejunum, via an in vivo in-situ thiol-disulfide exchange reaction between surface-reactive bacteria and mucous.
- Huilong Luo
- , Yanmei Chen
- & Jinyao Liu
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Article
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Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation
Nanoparticle elasticity is known to affect physiological fate but how this occurs is largely unknown. Here, the authors report on a study using nanoparticles differing in elasticity alone to show a difference in the protein corona, in particular apolipoprotein A-1 absorption, corresponds to differences in circulation time.
- Mingyang Li
- , Xinyang Jin
- & Lihua Yang
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Article
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Ultrafast energy relaxation dynamics of amide I vibrations coupled with protein-bound water molecules
Vibrational energy relaxation of proteins helps us to understand ultrafast protein dynamics. Here, the authors determine the vibrational energy transfer time of the amide I mode in aqueous environment and find that water provides a “shortcut” through a direct resonant channel to dissipate energy into the solvent.
- Junjun Tan
- , Jiahui Zhang
- & Shuji Ye
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Article
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Monolayer surface chemistry enables 2-colour single molecule localisation microscopy of adhesive ligands and adhesion proteins
To date, the precise localisation of ligands and adhesion proteins are determined in two parallel characterization setups. Here, the authors report a self-assembled monolayer chemistry for indium tin oxide surfaces allowing single molecule localisation microscopy (SMLM) imaging of ligands and adhesion proteins in a single experiment.
- Xun Lu
- , Philip R. Nicovich
- & J. Justin Gooding
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Article
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Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery
Despite their potential application as drug-delivery carriers, covalent organic frameworks (COF) have been only evaluated in vitro. Here the authors show by real time tracking in vivo the cell uptake of anticancer-drug loaded and water dispersible COFs.
- Guiyang Zhang
- , Xinle Li
- & Xudong Jia
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Article
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Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides
Capture of low-abundance multiply phosphorylated peptides (MPPs) is difficult due to limitation of enrichment materials and their interactions with phosphates. Here the authors show, a smart polymer driven by specific but tunable hydrogen bonding interactions can differentially complex with MPPs, singly phosphorylated and non-modified peptides.
- Guangyan Qing
- , Qi Lu
- & Taolei Sun
Probing the surface charge of condensates using microelectrophoresis