Biosensors articles within Nature

Featured

  • Article |

    A modular de novo designed biosensor platform consisting of a cage and key molecule is developed, and used to create sensors for seven distinct proteins including the spike protein from SARS-CoV-2 and anti-SARS antibodies.

    • Alfredo Quijano-Rubio
    • , Hsien-Wei Yeh
    •  & David Baker

  • Article |

    Lateral-flow in vitro diagnostic assays based on fluorescent nanodiamonds, in which microwave-based spin manipulation is used to increase sensitivity, are demonstrated using the biotin–avidin model and by the single-copy detection of HIV-1 RNA.

    • Benjamin S. Miller
    • , Léonard Bezinge
    •  & Rachel A. McKendry

  • Letter |

    Genome-wide association studies are used to identify common genetic variants that affect the structure of selected subcortical regions of the human brain; their identification provides insight into the causes of variability in brain development and may help to determine mechanisms of neuropsychiatric dysfunction.

    • Derrek P. Hibar
    • , Jason L. Stein
    •  & Sarah E. Medland

  • Letter |

    A nanoscale thermometry technique that uses coherent manipulation of the electronic spin associated with nitrogen–vacancy colour centres in diamond makes it possible to detect temperature variations as small as 1.8 millikelvin in ultrapure samples and to control and map temperature gradients within living cells.

    • G. Kucsko
    • , P. C. Maurer
    •  & M. D. Lukin

  • Article |

    Thousands of quorum-sensing Escherichia coli colonies are synchronized over centimetres using redox signalling to create ‘biopixels’ that can sense trace amounts of arsenic in water.

    • Arthur Prindle
    • , Phillip Samayoa
    •  & Jeff Hasty

  • Letter |

    The ability of cells to respond to physical forces is central to development and physiology, but until now it has been difficult to directly measure forces across proteins in vivo. Here, however, a calibrated biosensor is described that can measure forces with high sensitivity across specific proteins in cells. This is applied to the vinculin protein, and a regulatory mechanism is revealed in which the force applied to vinculin determines whether focal adhesions assemble or disassemble.

    • Carsten Grashoff
    • , Brenton D. Hoffman
    •  & Martin A. Schwartz

  • News & Views |

    Measuring the tension forces at specific sites in living cells is technically challenging. Now, a fluorescent biosensor protein can be used to characterize dynamic local changes in tension in migrating cells.

    • Andrew D. Doyle
    •  & Kenneth M. Yamada

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