Biophysical methods articles within Nature Materials

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  • Article |

    Precise manipulation of colloids and cells is desired for material and life sciences. However, such control remains challenging without material modifications. Here, the authors achieve reversible single-particle manipulation with subwavelength resolution and high throughput using harmonic acoustics.

    • Shujie Yang
    • , Zhenhua Tian
    •  & Tony Jun Huang

  • Article |

    Atomic force microscopy indentation measurements of cells cultured on soft substrates may result in an underestimation of cell stiffness. A model has now been developed that takes this soft substrate effect into account, revealing that cortical cell stiffness is largely independent of substrate mechanics.

    • Johannes Rheinlaender
    • , Andrea Dimitracopoulos
    •  & Kristian Franze

  • Article |

    A mechanism of cell response to localized tension shows that syndecan-4 synergizes with EGFR to elicit a mechanosignalling cascade that leads to adaptive cell stiffening through PI3K/kindlin-2 mediated integrin activation.

    • Antonios Chronopoulos
    • , Stephen D. Thorpe
    •  & Armando E. del Río Hernández

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