Biological models articles within Nature

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  • Article
    | Open Access

    Following testing of magnetic field effects on 97,658 flies moving in a two-arm maze and on 10,960 flies performing spontaneous escape behaviour (negative geotaxis), no evidence was found for magnetically sensitive behaviour in Drosophila.

    • Marco Bassetto
    • , Thomas Reichl
    •  & Henrik Mouritsen

  • Letter |

    Neural blastocyst complementation creates a vacant forebrain niche in host embryos that can be populated by donor embryonic stem cell-derived dorsal telencephalic progenitors, resulting in a mouse brain organogenesis model.

    • Amelia N. Chang
    • , Zhuoyi Liang
    •  & Frederick W. Alt

  • Perspective |

    This work highlights the critical challenges in experimental design and interpretation due to important combinatorial effects of host and microbial genes, and calls for the development of minimal reporting requirements to improve the interpretation and reproducibility of experimental biology.

    • Thaddeus S. Stappenbeck
    •  & Herbert W. Virgin

  • Article |

    Here the authors present a human pluripotent stem cell-derived three-dimensional organoid culture system that is able to recapitulate several aspects of human brain development in addition to modelling the brain disorder microcephaly, which has been difficult to achieve using mouse models.

    • Madeline A. Lancaster
    • , Magdalena Renner
    •  & Juergen A. Knoblich

  • Outlook |

    Despite some outstanding drug-development successes, the mouse version of multiple sclerosis has been worryingly unreliable at screening human treatments.

    • Jocelyn Rice

  • World View |

    Many of the studies that use animals to model human diseases are too small and too prone to bias to be trusted, says Malcolm Macleod.

    • Malcolm Macleod

  • Technology Feature |

    Monitoring technologies and genetic engineering are producing a growing array of animal models for psychiatric disorders, but researchers are still learning how best to use them.

    • Monya Baker

  • News & Views |

    Theoretical models of the dynamics of self-driven systems predict the collective motion of biological systems, such as insect swarms. An experimental model has been developed to test the predictions.

    • Jean-François Joanny
    •  & Sriram Ramaswamy

  • Outlook |

    The lack of a good animal model is frustrating efforts to curb disease progression, explains M. Flint Beal.

    • M. Flint Beal

  • Opinion |

    Many researchers avoid using female animals. Stringent measures should consign this prejudice to the past, argue Irving Zucker and Annaliese Beery, in the third piece of three on gender bias in biomedicine.

    • Irving Zucker
    •  & Annaliese K. Beery

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