Bioinorganic chemistry

Bioinorganic chemistry is the study of the structures and biological functions of inorganic biological substances, that is, those not containing carbon, such as metals.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Bacteria sense metal ions using proteins whose interactions with DNA are sensitive to metal ion availability and identity. Less competitive metal ions trigger protein–DNA binding only at high concentrations.

    • David Schilter
  • News and Views |

    Superoxide dismutase mimics can help regulate the levels of O2•− in the body, but typically rely on redox-active metals that are toxic in their free form. Now, a complex featuring a redox-active quinol moiety complexed to a redox-inactive zinc centre has been shown to catalyse O2•− dismutation.

    • Diane E. Cabelli
    Nature Chemistry 10, 1173-1175
  • News and Views |

    Artificial metalloenzymes generally consist of a synthetic (organo)metallic catalyst incorporated into a protein. Asymmetric catalysis by such metalloenzymes could result by virtue of the chiral protein environment. Now, redox-sensitive anchoring enables reversible incorporation of an iridium catalyst for transfer hydrogenation.

    • Jun Okuda
    Nature Catalysis 1, 639-640
  • Editorial |

    Enzymes can serve as blueprints for artificial catalysts, the preparation of which may involve anything from biosynthesis of mutants to chemical synthesis of active site mimics.