Bioinorganic chemistry

Definition

Bioinorganic chemistry is the study of the structures and biological functions of inorganic biological substances, that is, those not containing carbon, such as metals.

Latest Research and Reviews

  • Research |

    The structure of the hydrogenase-maturation protein HydF in the holo form with its [4Fe-4S] cluster reveals a labile glutamate ligand that allows binding of artificial 2Fe subcluster mimics, thus endowing HydF with its own hydrogenase activity.

    • Giorgio Caserta
    • , Ludovic Pecqueur
    • , Agnieszka Adamska-Venkatesh
    • , Cecilia Papini
    • , Souvik Roy
    • , Vincent Artero
    • , Mohamed Atta
    • , Edward Reijerse
    • , Wolfgang Lubitz
    •  & Marc Fontecave
  • Research |

    The oxidative prowess of cytochrome P450s has been suggested to stem from the electron-donating axial ligand. Now, a selenocysteine-ligated P450 compound I has been trapped and characterized providing an avenue to examine this hypothesis. Measurements reveal that the selenolate-ligated compound I cleaves C–H bonds more rapidly than the wild-type equivalent.

    • Elizabeth L. Onderko
    • , Alexey Silakov
    • , Timothy H. Yosca
    •  & Michael T. Green
  • Research | | open

    Lanthanide elements are difficult to separate from aqueous solution with low energy input. Here, the authors design a peptide that recognizes and drives the precipitation of an insoluble lanthanide complex under physiological conditions, introducing a biomineralization-based approach for rare earth recovery.

    • Takaaki Hatanaka
    • , Akimasa Matsugami
    • , Takamasa Nonaka
    • , Hideki Takagi
    • , Fumiaki Hayashi
    • , Takao Tani
    •  & Nobuhiro Ishida
  • Research | | open

    Trimeric intracellular cation channels (TRICs) elicit K+ currents to counteract luminal negative potential during Ca2+ release from intracellular stores. Here the authors present structures of prokaryotic TRICs in their open and closed states, obtaining molecular insight into TRICs’ function.

    • Min Su
    • , Feng Gao
    • , Qi Yuan
    • , Yang Mao
    • , De-lin Li
    • , Youzhong Guo
    • , Cheng Yang
    • , Xiao-hui Wang
    • , Renato Bruni
    • , Brian Kloss
    • , Hong Zhao
    • , Yang Zeng
    • , Fa-ben Zhang
    • , Andrew R Marks
    • , Wayne A Hendrickson
    •  & Yu-hang Chen
  • Research | | open

    The mitochondrial proteins ISCA1 and ISCA2 form a complex that is involved in the biogenesis of Fe–S clusters. Here the authors report that ISCA1 and ISCA2 interact differently with proteins of the Fe–S machinery and that under certain conditions, ISCA2 seems dispensable for Fe–S biogenesis.

    • Lena Kristina Beilschmidt
    • , Sandrine Ollagnier de Choudens
    • , Marjorie Fournier
    • , Ioannis Sanakis
    • , Marc-André Hograindleur
    • , Martin Clémancey
    • , Geneviève Blondin
    • , Stéphane Schmucker
    • , Aurélie Eisenmann
    • , Amélie Weiss
    • , Pascale Koebel
    • , Nadia Messaddeq
    • , Hélène Puccio
    •  & Alain Martelli

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