Bioinformatics articles within Nature Reviews Nephrology

Featured

  • Review Article |

    Spatially resolved transcriptomic technologies enable the mapping of transcripts at single-cell or near single-cell resolution in a multiplex manner. This Review describes current and emerging spatial transcriptomic methods, their applications of relevance to kidney biology and remaining challenges for the field.

    • Sanjay Jain
    •  & Michael T. Eadon

  • Review Article |

    Dyslipidaemia is a hallmark of chronic kidney disease (CKD), with insights from lipidomics studies suggesting that alterations in free fatty acid partitioning may contribute to CKD progression. This Review provides an introduction to lipidomics and discusses insights from lipidomics studies of relevance to CKD.

    • Judy Baek
    • , Chenchen He
    •  & Subramaniam Pennathur

  • News & Views |

    A new study discovered thousands of expression quantitative trait loci (eQTLs) in the renal glomerular and tubulointerstitial compartments and integrated these data with other omics data sets to identify genes with roles in the pathogenesis of chronic kidney disease. This report reinforces the necessity of using compartment-derived eQTLs to advance kidney genomic discovery.

    • Matthew G. Sampson

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