Biliary tract articles within Nature Communications

Featured

• Article
  30 November 2023 | Open Access

  Bile proteome reveals biliary regeneration during normothermic preservation of human donor livers

  Normothermic machine perfusion (NMP) is increasingly used for preserving and evaluating donor livers before transplantation. Here, the authors demonstrate increased regenerative protein profiles in the bile of perfused livers considered suitable for transplantation, providing insight into the mechanisms linked to recovery of the biliary tree following ischemia-reperfusion injury.

  • Adam M. Thorne
  • , Justina C. Wolters
  •  & Vincent E. de Meijer

• Matters Arising
  12 February 2021 | Open Access

  Hypothermic machine perfusion before viability testing of previously discarded human livers

  • Otto B. van Leeuwen
  • , Yvonne de Vries
  •  & Robert J. Porte

• Article
  30 November 2018 | Open Access

  Genome-wide association meta-analysis yields 20 loci associated with gallstone disease

  Genome-wide association studies have so far identified eight risk loci for gallstone disease. Here, the authors perform meta-analysis in cohorts from Iceland and the UK which reveals further 21 common and low-frequency risk variants that highlight the role of bile acid homeostasis in gallstone disease.

  • Egil Ferkingstad
  • , Asmundur Oddsson
  •  & Kari Stefansson

• Article
  09 March 2018 | Open Access

  Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

  Senescence has been suggested as causing biliary cholangiopathies but how this is regulated is unclear. Here, the authors generate a mouse model of biliary senescence by deleting Mdm2 in bile ducts and show that inhibiting TGFβ limits senescence-dependent aggravation of cholangiopathies.

  • Sofia Ferreira-Gonzalez
  • , Wei-Yu Lu
  •  & Stuart J. Forbes