Featured
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This Month |
The LGBTQ+ job hunt
Job-hunting is never easy, and more tasks get added on for members of the LGBTQ+ community as they search for welcoming environments.
- Vivien Marx
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Brief Communication |
A modular architecture for organizing, processing and sharing neurophysiology data
A modular architecture for managing and sharing electrophysiology, behavior, colony management and other data has been built to support individual laboratories or large consortia.
- Luigi Acerbi
- , Valeria Aguillon-Rodriguez
- & Miles J. Wells
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News & Views |
Tracking together: estimating social poses
Two new toolkits that leverage deep-learning approaches can track the positions of multiple animals and estimate poses in different experimental paradigms.
- Sena Agezo
- & Gordon J. Berman
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This Month |
Mackenzie Weygandt Mathis
Building a sustainable open source toolbox to track social behavior and how to get in the zone.
- Vivien Marx
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Article
| Open AccessMulti-animal pose estimation, identification and tracking with DeepLabCut
DeepLabCut is extended to enable multi-animal pose estimation, animal identification and tracking, thereby enabling the analysis of social behaviors.
- Jessy Lauer
- , Mu Zhou
- & Alexander Mathis
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Article |
Geometric deep learning enables 3D kinematic profiling across species and environments
DANNCE enables robust 3D tracking of animals’ limbs and other features in naturalistic environments by making use of a deep learning approach that incorporates geometric reasoning. DANNCE is demonstrated on behavioral sequences from rodents, marmosets, and chickadees.
- Timothy W. Dunn
- , Jesse D. Marshall
- & Bence P. Ölveczky
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Brief Communication |
A three-dimensional virtual mouse generates synthetic training data for behavioral analysis
Bolaños et al. present a realistic three-dimensional virtual mouse model that can be animated and that facilitates the training of pose estimation algorithms.
- Luis A. Bolaños
- , Dongsheng Xiao
- & Timothy H. Murphy
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Article |
EthoLoop: automated closed-loop neuroethology in naturalistic environments
EthoLoop enables real-time tracking and behavioral analysis of animals in naturalistic environments and can be combined with behavioral conditioning, optogenetic stimulation or wireless recording of neural activity. The system is illustrated with freely behaving mice and mouse lemurs.
- Ali Nourizonoz
- , Robert Zimmermann
- & Daniel Huber
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News & Views |
Plankton in a hamster wheel
Plankton regularly travel vast distances up and down in the ocean. A water-filled hamster wheel with glass windows now enables detailed microscopic lab observations of individual aquatic microorganisms during their vertical migrations.
- Katja M. Taute
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Article |
A virtual reality system to analyze neural activity and behavior in adult zebrafish
Complex behaviors and the underlying neural activity in adult zebrafish can be accessed through a virtual reality system in combination with two-photon microscopy.
- Kuo-Hua Huang
- , Peter Rupprecht
- & Rainer W. Friedrich
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Correspondence |
An open-source platform for analyzing and sharing worm-behavior data
- Avelino Javer
- , Michael Currie
- & André E. X. Brown
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Research Highlight |
Correlating behavior and neural activity at high resolution
A combination of behavioral analysis and neural activity recording provides a glimpse into how the brain orchestrates complex behaviors.
- Nina Vogt
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Methods in Brief |
Mice at the steering wheel
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Article |
Virtual reality for freely moving animals
FreemoVR is a virtual reality system for freely moving animals. The versatile platform is demonstrated in various experiments with Drosophila, zebrafish, and mice.
- John R Stowers
- , Maximilian Hofbauer
- & Andrew D Straw
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Brief Communication |
Flyception: imaging brain activity in freely walking fruit flies
Flyception is a tracking and imaging system that enables the monitoring of brain activity in freely walking fruit flies, making the analysis of calcium dynamics possible in studies of neural mechanisms such as those that underlie social behaviors.
- Dhruv Grover
- , Takeo Katsuki
- & Ralph J Greenspan
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Brief Communication |
TRP channel mediated neuronal activation and ablation in freely behaving zebrafish
Heterologous TRP channels can be used to stimulate or ablate neurons in response to their chemical or thermal agonists in zebrafish larvae, providing a set of tools orthogonal to optogenetic manipulation.
- Shijia Chen
- , Cindy N Chiu
- & David A Prober
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Brief Communication |
Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation
A robotic system is described that uses machine vision guidance to pick, manipulate, inspect and dissect individual flies, enabling large-scale and automated approaches to the analysis of morphology, behavior and neural dynamics.
- Joan Savall
- , Eric Tatt Wei Ho
- & Mark J Schnitzer
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Methods in Brief |
Electrophysiology in a virtual world
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News & Views |
Animal identification with robot rovers
Robots can be used to detect marked animals with less disturbance when assessing ecological drivers of population change.
- Philip N Trathan
- & Louise Emmerson
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Brief Communication |
Rovers minimize human disturbance in research on wild animals
This paper investigates the stress levels and behavior of wild animals when approached by remote-operated vehicles versus humans for data collection in field research
- Yvon Le Maho
- , Jason D Whittington
- & Céline Le Bohec
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This Month |
Alexei Vyssotski
An avian backpack for discerning individual zebra finches' songs and studying cognition comes to Switzerland via Novosibirsk, Russia.
- Vivien Marx
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Brief Communication |
Reconstruction of vocal interactions in a group of small songbirds
Communications between animals such as zebra finches can be discriminated with back-attached acceleration recorders. In contrast to microphones, these devices record the carrier's signals only, allowing a more precise analysis of individual vocalizations during social interactions.
- Victor N Anisimov
- , Joshua A Herbst
- & Alexei L Vyssotski
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News & Views |
Distinguishing seemingly indistinguishable animals with computer vision
A general method to recognize and track unmarked animals within a population will enable new studies of social behavior and individuality.
- Kristin Branson
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This Month |
William Ja
Lessons from the volleyball court help to compare ways to measure how much flies eat.
- Vivien Marx
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Analysis |
Quantifying Drosophila food intake: comparative analysis of current methodology
This Analysis compares four commonly used assays to measure food intake in flies and identifies radioisotope-labeling and the capillary feeder (CAFE) as the most reproducible and sensitive.
- Sonali A Deshpande
- , Gil B Carvalho
- & William W Ja
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Brief Communication |
A database of Caenorhabditis elegans behavioral phenotypes
A growing collection of segmented and feature-extracted videos recording locomotive behavior in hundreds of C. elegans mutant strains is made available for phenotyping and further analysis.
- Eviatar Yemini
- , Tadas Jucikas
- & William R Schafer
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Correspondence |
Does systematic variation improve the reproducibility of animal experiments?
- Rudy M Jonker
- , Anja Guenther
- & Tim Schmoll
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Methods in Brief |
Worm behavioral motifs
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Brief Communication |
JAABA: interactive machine learning for automatic annotation of animal behavior
Open-source software that allows biologists to create a variety of behavior classifiers for automatically annotating video of behaving animals is presented. The program, called JAABA, uses state-of-the-art machine-learning methods and is applicable to tracking data from different organisms, including mice and adult and larval Drosophila.
- Mayank Kabra
- , Alice A Robie
- & Kristin Branson
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Commentary |
Measuring behavior of animal models: faults and remedies
Widely used behavioral assays need re-evaluation and validation against their intended use. We focus here on measures of chronic anxiety in mouse models and posit that widely used assays such as the open-field test are performed at the wrong time, for inadequate durations and using inappropriate mouse strains. We propose that behavioral assays be screened for usefulness on the basis of their replicability across laboratories.
- Ehud Fonio
- , Ilan Golani
- & Yoav Benjamini
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Technology Feature |
Rendering the brain-behavior link visible
In vivo imaging scientists broadcast from inside the brains of moving animals.
- Vivien Marx
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Methods in Brief |
Virtual swimmers
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Research Highlights |
Drosophila's outdoor schedule
Fly rhythms under natural light and temperature differ from those in the lab.
- Monya Baker
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Research Highlights |
A technology for memory
Two methodological approaches allow researchers to manipulate the formation and reactivation of memories in mice.
- Erika Pastrana
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Editorial |
Building a better mouse test
As more mouse models are produced, researchers studying neuropsychiatric diseases will need better ways to evaluate them and more realistic assessment of the results.
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Article |
High-content behavioral analysis of Caenorhabditis elegans in precise spatiotemporal chemical environments
Quantitative analysis of Caenorhabditis elegans chemosensory behavior is achieved in a structured arena with microfluidic delivery of stimuli with precise spatial and temporal control. Also in this issue, Swierczek et al. report software for real-time behavioral analysis in worms.
- Dirk R Albrecht
- & Cornelia I Bargmann
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Brief Communication |
Taming anxiety in laboratory mice
Mice handled by their tails show high levels of anxiety and stress compared to mice handled in cupped hands or in a transparent tunnel.
- Jane L Hurst
- & Rebecca S West
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News & Views |
Do mice have a pain face?
Assessing changes in facial expression may enable us to assess pain in animals more accurately and more effectively.
- Paul A Flecknell
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This Month |
Jeffrey Mogil
Putting a face on pain in mice should improve our ability to measure it.
- Monya Baker
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Research Highlights |
Neurons light the way
Monitoring the activity of neurons in vivo in the freely behaving zebrafish larvae is now possible using bioluminescence, an approach with great potential for unveiling how neuronal networks control behavior.
- Erika Pastrana
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Correspondence |
Systematic variation improves reproducibility of animal experiments
- S Helene Richter
- , Joseph P Garner
- & Hanno Würbel