Featured
-
-
Article
| Open Access
Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury
A common cellular manifestation for diverse kidney diseases is dysregulated actin cytoskeleton in distinct cell types that include glomerular podocytes and tubular epithelial cells. Here, authors pharmacologically activate dynamin and this results in polymerization and crosslinking of actin filaments to establish the structural integrity of these cells, thus ameliorating disease phenotypes.
- Kamalika Mukherjee
- , Changkyu Gu
- & Sanja Sever
-
Article
| Open Access
Mouse embryo geometry drives formation of robust signaling gradients through receptor localization
How receptor localization affects morphogen gradient formation during embryonic development is unclear. Here, the authors study the relationship between the BMP gradient, receptor localization, and compartmentalized geometry in the early mouse embryo, using experimental data and computational simulation.
- Zhechun Zhang
- , Steven Zwick
- & Sharad Ramanathan
Dynamic interactions between E-cadherin and Ankyrin-G mediate epithelial cell polarity maintenance