Basal cell carcinoma articles within Nature

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• Letter | 08 October 2018

  A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition

  When basal cell carcinoma is treated with a Smoothened inhibitor, a subset of cancer cells evades treatment by switching identity, allowing residual tumours to regrow when treatment is discontinued.

  • Brian Biehs
  • , Gerrit J. P. Dijkgraaf
  •  & Frederic J. de Sauvage

• Letter | 08 October 2018

  A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy

  Treatment of basal cell carcinoma with Smoothened inhibitors leaves a small population of quiescent cells that can drive relapse but can be eliminated by additional treatment with a Wnt signalling inhibitor.

  • Adriana Sánchez-Danés
  • , Jean-Christophe Larsimont
  •  & Cédric Blanpain

• Article | 08 July 2016

  Defining the clonal dynamics leading to mouse skin tumour initiation

  Skin stem cells, but not their progenitors, are able to form tumours owing to the ability of oncogene-targeted stem cells to increase symmetric self-renewing division and a higher p53-dependent resistance to apoptosis.

  • Adriana Sánchez-Danés
  • , Edouard Hannezo
  •  & Cédric Blanpain