Bacterial systems biology

Bacterial systems biology is the scientific study of the functions and properties of bacteria in an integrative, systematic way, based on the analysis and modelling of large data sets. Systems biology is, for example, used to build networks of bacterial metabolism.

Latest Research and Reviews

News and Comment

  • News and Views |

    It has been assumed that bacteria adapt to nutrient limitation by adjusting the number of ribosomes, no matter what they are being starved for. Instead, two recent studies show that Escherichia coli uses different approaches depending on whether its growth is limited by the availability of carbon, nitrogen or phosphate.

    • Katarzyna Potrykus
    •  & Michael Cashel
    Nature Microbiology 3, 862-863
  • News and Views |

    The incorporation of additional gene circuits into hosts can often lead to unpredicted and undesirable behaviours. Recent work has developed a modelling framework that accounts for host–circuit interactions and can predict a variety of phenotypes at both single-cell and population levels.

    • Sandra J. Aedo
    • , Grant Gelderman
    •  & Mark P. Brynildsen
    Nature Microbiology 2, 1584-1585
  • News and Views |

    The use of levulinic acid in bioconversion strategies has been limited by the lack of information on the pathways used by microorganisms to degrade it. Now, functional genomics reveals the essential steps for utilization of levulinic acid in Pseudomonas putida.

    • Kristina Haslinger
    •  & Kristala L. J. Prather
    Nature Microbiology 2, 1580-1581