Applied immunology

Definition

Applied immunology provides services to support the development of biological therapeutics such as monoclonal antibodies, vaccines and diagnostics. Applied immunology is a subdiscipline of immunology.

Featured

Latest Research and Reviews

  • Research | | open

    An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1 infected individual.

    • Wilton B. Williams
    • , Jinsong Zhang
    • , Chuancang Jiang
    • , Nathan I. Nicely
    • , Daniela Fera
    • , Kan Luo
    • , M. Anthony Moody
    • , Hua-Xin Liao
    • , S. Munir Alam
    • , Thomas B. Kepler
    • , Akshaya Ramesh
    • , Kevin Wiehe
    • , James A. Holland
    • , Todd Bradley
    • , Nathan Vandergrift
    • , Kevin O. Saunders
    • , Robert Parks
    • , Andrew Foulger
    • , Shi-Mao Xia
    • , Mattia Bonsignori
    • , David C. Montefiori
    • , Mark Louder
    • , Amanda Eaton
    • , Sampa Santra
    • , Richard Scearce
    • , Laura Sutherland
    • , Amanda Newman
    • , Hilary Bouton-Verville
    • , Cindy Bowman
    • , Howard Bomze
    • , Feng Gao
    • , Dawn J. Marshall
    • , John F. Whitesides
    • , Xiaoyan Nie
    • , Garnett Kelsoe
    • , Steven G. Reed
    • , Christopher B. Fox
    • , Kim Clary
    • , Marguerite Koutsoukos
    • , David Franco
    • , John R. Mascola
    • , Stephen C. Harrison
    • , Barton F. Haynes
    •  & Laurent Verkoczy
  • Research | | open

    Eliciting broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal, but available immunogens expose epitopes for development of non-nAbs. Here, the authors use computational and structure-guided design to develop improved native-like envelope trimers and analyze Ab response in animal models.

    • Daniel W. Kulp
    • , Jon M. Steichen
    • , Matthias Pauthner
    • , Xiaozhen Hu
    • , Torben Schiffner
    • , Alessia Liguori
    • , Christopher A. Cottrell
    • , Colin Havenar-Daughton
    • , Gabriel Ozorowski
    • , Erik Georgeson
    • , Oleksandr Kalyuzhniy
    • , Jordan R. Willis
    • , Michael Kubitz
    • , Yumiko Adachi
    • , Samantha M. Reiss
    • , Mia Shin
    • , Natalia de Val
    • , Andrew B. Ward
    • , Shane Crotty
    • , Dennis R. Burton
    •  & William R. Schief
  • Research | | open

    Neutralizing antibodies to oligomannose glycans on HIV Env are difficult to elicit, possibly due to B cell tolerance. Here, Pantophlet et al. synthesize mimetics based on a bacterial oligosaccharide and show that they evoke HIV-neutralizing antibody responses in animals with a human Ig repertoire.

    • Ralph Pantophlet
    • , Nino Trattnig
    • , Sasha Murrell
    • , Naiomi Lu
    • , Dennis Chau
    • , Caitlin Rempel
    • , Ian A. Wilson
    •  & Paul Kosma
  • Research | | open

    Plasmodium falciparum protein Pfs25 is a promising malaria transmission blocking vaccine antigen. Here, Scally et al. determine the crystal structure of Pfs25 and identify antigenic sites that are recognized by transmission-blocking antibodies elicited in human immunoglobulin loci transgenic mice.

    • Stephen W. Scally
    • , Brandon McLeod
    • , Alexandre Bosch
    • , Kazutoyo Miura
    • , Qi Liang
    • , Sean Carroll
    • , Sini Reponen
    • , Ngan Nguyen
    • , Eldar Giladi
    • , Sebastian Rämisch
    • , Vidadi Yusibov
    • , Allan Bradley
    • , Franck Lemiale
    • , William R. Schief
    • , Daniel Emerling
    • , Paul Kellam
    • , C. Richter King
    •  & Jean-Philippe Julien
  • Research | | open

    An efficient vaccine for human metapneumovirus (hMPV) will likely rely on neutralizing antibodies against the fusion protein (F). Here, the authors determine the crystal structure of pre-fusion-stabilized hMPV F and identify a dense glycan shield that affects generation of neutralizing antibodies.

    • Michael B. Battles
    • , Vicente Más
    • , Eduardo Olmedillas
    • , Olga Cano
    • , Mónica Vázquez
    • , Laura Rodríguez
    • , José A. Melero
    •  & Jason S. McLellan

News and Comment

  • Comments and Opinion |

    Tracking who receives vaccines is essential, but will be impossible without innovations in digital technologies, says Seth Berkley.

    • Seth Berkley
    Nature 551, 273
  • News and Views |

    Dysfunctional immunity is associated with dengue hemorrhagic fever and dengue shock syndrome. Structural analyses reveal that a key germline-encoded contact between the T cell antigen receptor and a peptide underpins the immunodominance of dengue-virus-specific CD8+ T cell responses of weak affinity.

    • Sydney Blevins
    •  & Eric S Huseby
    Nature Immunology 18, 1186–1188
  • News and Views |

    Antimicrobial resistance in Neisseria gonorrhoeae compromises gonorrhoea treatment globally and vaccines might be the only sustainable solution for gonorrhoea control. A new study for the first time provides a proof of principle for protection with 31% effectiveness against gonorrhoea, owing to cross-protection by the outer membrane vesicle Neisseria meningitidis serogroup B vaccine (MeNZB).

    • Magnus Unemo
    •  & Aleksandra E. Sikora