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Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2
Isolates of authentic SARS-CoV-2 variants BA.1 and BA.2 exhibit similar infectivity and pathogenicity and show susceptibility to neutralizing therapeutic antibodies and antiviral compounds in mouse and hamster models.
- Ryuta Uraki
- , Maki Kiso
- & Yoshihiro Kawaoka
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Article
| Open AccessAntibody evasion properties of SARS-CoV-2 Omicron sublineages
A study reports on the antigenic characterization of SARS-CoV-2 BA.1, BA.1.1 and BA.2 and the neutralizing activity of different monoclonal antibodies and sera against them.
- Sho Iketani
- , Lihong Liu
- & David D. Ho
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Article |
Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike
A diverse collection of potent neutralizing antibodies against the SARS-CoV-2 spike protein have been isolated from five patients with severe COVID-19 and high serum neutralization titres.
- Lihong Liu
- , Pengfei Wang
- & David D. Ho
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Article |
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
A new treatment, containing an optimized cocktail of three monoclonal antibodies against Ebola virus, provided full protection and disease reversal in rhesus monkeys when given under conditions in which controls succumbed by day 8; this new therapy may be a good candidate for treating Ebola virus infection in human patients.
- Xiangguo Qiu
- , Gary Wong
- & Gary P. Kobinger
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News |
New drugs for hepatitis C on the horizon
With the promise of two new drugs, doctors see hope for a better-tailored cocktail.
- Katherine Harmon
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Outlook |
The outlook for a cure
There is a formidable arsenal of drugs available to treat HIV. Virginia Hughes finds that, for the first time in years, there is also renewed hope of a cure.
- Virginia Hughes
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Research Highlights |
Immunology: Double punch for HIV