Antiphospholipid syndrome

Antiphospholipid syndrome is an autoimmune connective tissue disease characterized by vascular thrombosis and pregnancy morbidity in the presence of antiphospholipid antibodies, namely lupus anticoagulant, anticardiolipin antibodies and anti-β2 glycoprotein-I antibody. Antiphospholipid syndrome can occur on its own or in association with other rheumatic diseases, most commonly systemic lupus erythematosus.

Latest Research and Reviews

  • Reviews |

    Vascular and obstetric antiphospholipid syndrome are associated with the same pathogenic antiphospholipid antibodies but differ with respect to their associated clinical manifestations. The expression and distribution of β2 glycoprotein I, the main target of antiphospholipid antibodies, might explain these differences.

    • Pier Luigi Meroni
    • , Maria Orietta Borghi
    • , Claudia Grossi
    • , Cecilia Beatrice Chighizola
    • , Paolo Durigutto
    •  & Francesco Tedesco
  • Reviews |

    Antiphospholipid syndrome is an autoimmune disease associated with a variety of symptoms, including thrombosis and obstetrical complications. This Primer provides an update on the epidemiology, pathogenesis, diagnosis and therapeutic aspects and offers an outlook on future research topics.

    • Karen Schreiber
    • , Savino Sciascia
    • , Philip G. de Groot
    • , Katrien Devreese
    • , Soren Jacobsen
    • , Guillermo Ruiz-Irastorza
    • , Jane E. Salmon
    • , Yehuda Shoenfeld
    • , Ora Shovman
    •  & Beverley J. Hunt
  • Reviews |

    The range of clinical manifestations and autoantibodies that are recognized as important in antiphosphlipid syndrome (APS) is constantly increasing. How can disease manifestations and autoantibodies that fall outside of the classic APS criteria be incorporated into diagnosis in the future?

    • Savino Sciascia
    • , Mary-Carmen Amigo
    • , Dario Roccatello
    •  & Munther Khamashta
  • Reviews |

    Some aspects of the management of antiphospholipid syndrome (APS) are supported by abundant high-quality evidence, but, in certain scenarios, decisions are based on clinical judgement and experience. This comprehensive Review surveys the current recommendations for treating thrombotic and obstetric manifestations of APS, and addresses several areas of controversy in APS diagnosis and management.

    • Gerard Espinosa
    •  & Ricard Cervera
  • Reviews |

    Autoantibody testing is key for the diagnosis, classification and management of systemic autoimmune rheumatic diseases; however, issues regarding the reproducibility and reliability of these tests currently limit their usefulness. Approaches to harmonize autoantibody tests, including the development of technical guidelines and the availability of suitable reference materials for calibration and quality control, are discussed in this Review.

    • Pier Luigi Meroni
    • , Martina Biggioggero
    • , Silvia S. Pierangeli
    • , Joanna Sheldon
    • , Ingrid Zegers
    •  & Maria Orietta Borghi