Aneuploidy articles within Nature

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• Letter | 29 January 2012

  Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy

  Aneuploidy is shown to be induced by pleiotropic stress conditions (especially Hsp90 inhbition) in yeast, leading to stress adaptation.

  • Guangbo Chen
  • , William D. Bradford
  •  & Rong Li

• News & Views | 10 November 2010

  When abnormality is beneficial

  One might think that aneuploidy — having an abnormal number of chromosomes — would be harmful, and would reduce an organism's fitness. Not necessarily: it all depends on the type of aneuploidy and the associated conditions. See Letter p.321

  • Judith Berman

• Letter | 20 October 2010

  Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

  Profiling of a large set of aneuploid yeast strains grown under a variety of conditions demonstrates that aneuploidy can affect both the transcriptome and the proteome and can generate significant phenotypic variation that could lead to fitness gains.

  • Norman Pavelka
  • , Giulia Rancati
  •  & Rong Li