Analytical biochemistry articles within Nature Chemistry

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• Article | 05 June 2023

  A high-dimensional microfluidic approach for selection of aptamers with programmable binding affinities

  Generating aptamers for use as affinity reagents in analytical applications is important, but SELEX, the standard method for aptamer generation, is unable to select for pre-defined binding affinities. Now, by combining efficient particle display, high-performance microfluidic sorting and high-content bioinformatics, the method ‘Pro-SELEX’ can afford the quantitative generation of aptamers with programmable binding affinities.

  • Dingran Chang
  • , Zongjie Wang
  •  & Shana O. Kelley

• News & Views | 30 April 2021

  Signal transduction with a swing

  The continuous monitoring of proteins is a current challenge in medical diagnostics. A new electrochemical approach aiming to address this has been described. The method uses antibodies as a recognition element to achieve the real-time measurement of proteins in saliva in the mouth.

  • Kevin J. Cash
  •  & Kevin W. Plaxco