Adult stem cells articles within Nature

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  • Letter |

    Endogenous prostaglandin E2 (PGE2) is a potent regulator of haematopoietic stem cell (HSC) retention in the bone marrow; inhibition of endogenous PGE2 signalling by non-steroidal anti-inflammatory drugs results in enhanced HSC and haematopoietic progenitor cell mobility via E-prostanoid 4 (EP4) receptor antagonism.

    • Jonathan Hoggatt
    • , Khalid S. Mohammad
    •  & Louis M. Pelus

  • Letter |

    The hilum (a transitional region) of the mouse ovary is identified as a stem cell niche of the ovarian surface epithelium, and its cells are prone to malignant transformation after inactivation of common tumour suppressor genes, suggesting that they may be the origin of ovarian carcinoma.

    • Andrea Flesken-Nikitin
    • , Chang-Il Hwang
    •  & Alexander Yu. Nikitin

  • Letter |

    This study reports the identification of adult stem cells in the human parasite Schistosoma mansoni (blood fluke); the cells proliferate and differentiate into derivatives of multiple germ layers, and their maintenance requires a fibroblast growth factor receptor orthologue.

    • James J. Collins III
    • , Bo Wang
    •  & Phillip A. Newmark

  • Letter |

    During normal ageing a low rate of division of pre-existing cardiomyocytes, rather than progenitor cells, is responsible for cardiomyocyte genesis; this process is increased fourfold during myocardial infarction.

    • Samuel E. Senyo
    • , Matthew L. Steinhauser
    •  & Richard T. Lee

  • Letter |

    Adult neural stem and progenitor cells (NSPCs) show high levels of fatty acid synthase (Fasn)-dependent de novo lipogenesis, a process that is controlled by Spot14 to regulate the rate of proliferation; this indicates a functional coupling between the regulation of lipid metabolism and adult NSPC proliferation.

    • Marlen Knobloch
    • , Simon M. G. Braun
    •  & Sebastian Jessberger

  • Letter |

    Investigation of neural cells from post-mortem human brains and differentiated from patient-derived induced pluripotent stem cells shows that the LRRK2 mutation (G2019S) associated with familial and sporadic Parkinson's disease correlates with abnormalities at the nuclear envelope.

    • Guang-Hui Liu
    • , Jing Qu
    •  & Juan Carlos Izpisua Belmonte

  • News & Views |

    It has been unclear whether a uniform group of stem cells gives rise to most cells in the epidermis. A study reveals the presence of at least two stem-cell populations that have different proliferative abilities. See Article p.257

    • Laura De Rosa
    •  & Michele De Luca

  • Letter |

    Adult muscle stem cells are used as a model system to show that the microRNA pathway, and specifically miR-489, is essential for the maintenance of the quiescent state of an adult stem-cell population by suppressing a key proliferation factor, Dek.

    • Tom H. Cheung
    • , Navaline L. Quach
    •  & Thomas A. Rando

  • News & Views |

    The molecular clock machinery regulates organisms' responses to daily variations in the environment. One unexpected response seems to be temporal fine-tuning of stem-cell behaviour in the skin. See Article p.209

    • Lorena Aguilar-Arnal
    •  & Paolo Sassone-Corsi

  • Letter |

    Using a temporal series of growth factor manipulations to mimic embryonic intestinal development in culture, this study has successfully directed the differentiation of human pluripotent stem cells (both embryonic stem cells and induced pluripotent stem cells) into intestinal tissue. This approach may provide therapeutic benefit for disease studies.

    • Jason R. Spence
    • , Christopher N. Mayhew
    •  & James M. Wells

  • Letter |

    Multipotent stem cells expressing Lgr5 are known to generate all cell types of the intestinal epithelium (enterocytes, goblet cells, Paneth cells and enteroendocrine cells). A new study shows that Paneth cells have an essential role for intestinal crypt and stem cell maintenance by supplying essential niche signals to the Lgr5-expressing cells.

    • Toshiro Sato
    • , Johan H. van Es
    •  & Hans Clevers

  • Brief Communications Arising |

    • Sabine Conrad
    • , Markus Renninger
    •  & Thomas Skutella

  • Letter |

    Reproductive history influences breast cancer risk but the cellular mechanisms are unclear. Here it is shown that ovarian hormones regulate the size of the mammary stem cell pool in mice. The size of this pool increases when progesterone levels increase during the reproductive cycle. Progesterone probably regulates stem cell numbers through a paracrine mechanism involving induction of RANKL and Wnt in luminal cells.

    • Purna A. Joshi
    • , Hartland W. Jackson
    •  & Rama Khokha

  • Letter |

    The ovarian hormones oestrogen and progesterone increase breast cancer risk but the cellular mechanisms are unclear. Here it is shown that the size of the mammary stem cell pool in mice is regulated by steroid hormone signalling, although these cells lack the receptors for oestrogen and progesterone. The augmented pool could lead to clonal expansion of a mutated cell, possibly accounting for the increased incidence of breast cancer associated with pregnancy.

    • Marie-Liesse Asselin-Labat
    • , François Vaillant
    •  & Jane E. Visvader

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