Adult stem cells

Definition

Adult stem cells are cells in the adult that can both self-renew by dividing and give rise to more specialised cell types present in the tissue in which they reside. They serve to maintain and repair the tissue.

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Latest Research and Reviews

  • Research |

    An artificial recombination locus, Polylox, that can generate hundreds of thousands of individual barcodes is used to trace the fates of haematopoietic stem cells in mice.

    • Weike Pei
    • , Thorsten B. Feyerabend
    • , Jens Rössler
    • , Xi Wang
    • , Daniel Postrach
    • , Katrin Busch
    • , Immanuel Rode
    • , Kay Klapproth
    • , Nikolaus Dietlein
    • , Claudia Quedenau
    • , Wei Chen
    • , Sascha Sauer
    • , Stephan Wolf
    • , Thomas Höfer
    •  & Hans-Reimer Rodewald
  • Research |

    Flores et al. show that hair follicle stem cells rely on the production of lactate via the LDHA enzyme to become activated. Inducing Ldha through Mpc1 inhibition or Myc activation successfully reactivates the hair cycle in quiescent follicles.

    • Aimee Flores
    • , John Schell
    • , Abigail S. Krall
    • , David Jelinek
    • , Matilde Miranda
    • , Melina Grigorian
    • , Daniel Braas
    • , Andrew C. White
    • , Jessica L. Zhou
    • , Nicholas A. Graham
    • , Thomas Graeber
    • , Pankaj Seth
    • , Denis Evseenko
    • , Hilary A. Coller
    • , Jared Rutter
    • , Heather R. Christofk
    •  & William E. Lowry
  • Research |

    Schell et al. demonstrate that inactivation of the mitochondrial pyruvate carrier in mouse and fly intestinal stem cells (ISCs) locks the cell into a glycolytic metabolic program and promotes the expansion of the stem cell compartment.

    • John C. Schell
    • , Dona R. Wisidagama
    • , Claire Bensard
    • , Helong Zhao
    • , Peng Wei
    • , Jason Tanner
    • , Aimee Flores
    • , Jeffrey Mohlman
    • , Lise K. Sorensen
    • , Christian S. Earl
    • , Kristofor A. Olson
    • , Ren Miao
    • , T. Cameron Waller
    • , Don Delker
    • , Priyanka Kanth
    • , Lei Jiang
    • , Ralph J. DeBerardinis
    • , Mary P. Bronner
    • , Dean Y. Li
    • , James E. Cox
    • , Heather R. Christofk
    • , William E. Lowry
    • , Carl S. Thummel
    •  & Jared Rutter
  • Research | | open

    • Ryoichiro Doi
    • , Tomoshi Tsuchiya
    • , Norisato Mitsutake
    • , Satoshi Nishimura
    • , Mutsumi Matsuu-Matsuyama
    • , Yuka Nakazawa
    • , Tomoo Ogi
    • , Sadanori Akita
    • , Hiroshi Yukawa
    • , Yoshinobu Baba
    • , Naoya Yamasaki
    • , Keitaro Matsumoto
    • , Takuro Miyazaki
    • , Ryotaro Kamohara
    • , Go Hatachi
    • , Hideyori Sengyoku
    • , Hironosuke Watanabe
    • , Tomohiro Obata
    • , Laura E. Niklason
    •  & Takeshi Nagayasu

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