Adipocytes

Adipocytes are cells specialised in storing energy as fat, mainly triglycerides, in organelles called lipid droplets. There are two major types of adipocytes in mammals: white adipocytes contain one large lipid droplet and are involved in fat storage, whereas brown adipocytes have many smaller lipid droplets and numerous mitochondria that generate energy, maintaining body temperature.

Latest Research and Reviews

  • Research | | open

    The diversity of fibroblasts contributing to wound healing is unclear. Here, the authors use single-cell RNA-sequencing to identify heterogeneity among murine fibroblasts in the wound and find that recruited myeloid cells contribute to adipocyte regeneration during healing.

    • Christian F. Guerrero-Juarez
    • , Priya H. Dedhia
    • , Suoqin Jin
    • , Rolando Ruiz-Vega
    • , Dennis Ma
    • , Yuchen Liu
    • , Kosuke Yamaga
    • , Olga Shestova
    • , Denise L. Gay
    • , Zaixin Yang
    • , Kai Kessenbrock
    • , Qing Nie
    • , Warren S. Pear
    • , George Cotsarelis
    •  & Maksim V. Plikus
  • Reviews |

    This Review summarizes the current knowledge on the biology and regional variability of the adipose tissue, highlighting the molecular mechanisms controlling the crosstalk between the adipose tissue and the cardiovascular system. Current state-of-the-art techniques in adipose tissue imaging for cardiovascular risk stratification and the potential of the adipose tissue as a target for the treatment of cardiovascular disease are also described.

    • Evangelos K. Oikonomou
    •  & Charalambos Antoniades
  • Reviews |

    The brain regulates adipose tissue metabolism through sympathetic efferent pathways; in turn, adipose tissues relay energy-status information to the brain. This Review gives an overview of interactions between the brain and adipose tissues, with a particular focus on leptin as a regulator of these communications.

    • Alexandre Caron
    • , Syann Lee
    • , Joel K. Elmquist
    •  & Laurent Gautron
  • Research | | open

    Satellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation changes satellite cell fate towards brown adipocytes and delays muscle regeneration in mice.

    • Milica Tosic
    • , Anita Allen
    • , Dominica Willmann
    • , Christoph Lepper
    • , Johnny Kim
    • , Delphine Duteil
    •  & Roland Schüle

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