Featured
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| Open AccessMitigating stimulated Brillouin scattering in multimode fibers with focused output via wavefront shaping
The authors demonstrate a high-power delivery through a highly multimode optical fiber by shaping the incident wavefront of a laser beam to strongly suppress the stimulated Brillouin scattering in the fiber and simultaneously control the output beam profile.
- Chun-Wei Chen
- , Linh V. Nguyen
- & Hui Cao
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| Open AccessExploiting volumetric wave correlation for enhanced depth imaging in scattering medium
The authors achieve ultrahigh resolution and depth volumetric imaging in complex media by recording a volumetric reflection matrix covering individual wavelengths and angles and developing reconstruction algorithms based on volumetric wave correlation.
- Ye-Ryoung Lee
- , Dong-Young Kim
- & Wonshik Choi
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Article
| Open AccessComputational conjugate adaptive optics microscopy for longitudinal through-skull imaging of cortical myelin
The authors realize longitudinal deep-brain imaging through an intact mouse skull by constructing a high-speed reflection matrix microscope at 1.3 µm wavelength and developing a computational conjugate adaptive optics algorithm eliminating skull aberrations.
- Yongwoo Kwon
- , Jin Hee Hong
- & Wonshik Choi
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Article
| Open AccessFlexible-type ultrathin holographic endoscope for microscopic imaging of unstained biological tissues
Lensless fibre endoscopes are minimally invasive, but are often rigid and require calibration and fluorescence labelling. Here, the authors present a flexible endoscope based on a bare fibre bundle and a lensless Fourier holographic imaging configuration to detect weak reflections from unstained biological tissues.
- Wonjun Choi
- , Munkyu Kang
- & Wonshik Choi
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Article
| Open AccessIn vivo volumetric imaging of calcium and glutamate activity at synapses with high spatiotemporal resolution
Adaptive optics (AO) corrects sample aberrations and allows high spatial resolution at depth in vivo. Here the authors report an AO method for Bessel focus; they apply AO Bessel focus scanning fluorescence microscopy to volumetric imaging and measure synaptic calcium and glutamate activity in vivo.
- Wei Chen
- , Ryan G. Natan
- & Na Ji
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| Open AccessFast holographic scattering compensation for deep tissue biological imaging
Wavefront shaping is used to overcome scattering in biological tissues during imaging, but determining the compensation is slow. Here, the authors use holographic phase stepping interferometry, where new phase information is updated after each measurement, enabling fast improvement of the wavefront correction.
- Molly A. May
- , Nicolas Barré
- & Alexander Jesacher
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| Open AccessRobust adaptive optics for localization microscopy deep in complex tissue
It is difficult to apply SMLM to complex biological tissues. Here the authors report REALM, Robust and Effective Adaptive Optics in Localisation Microscopy, to improve SMLM in tissue and use this to resolve the organisation of spectrin in the axon initial segment in brain tissue.
- Marijn E. Siemons
- , Naomi A. K. Hanemaaijer
- & Lukas C. Kapitein
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| Open AccessSubcellular three-dimensional imaging deep through multicellular thick samples by structured illumination microscopy and adaptive optics
Optical aberrations in Structured Illumination Microscopy (SIM) can lead to loss of resolution and artifacts making it unsuitable for thick samples. Here the authors combine Adaptive Optics and SIM (AO-3DSIM) to improve the 3D resolution and reduce artifacts, performing 3D-SIM in C.elegans.
- Ruizhe Lin
- , Edward T. Kipreos
- & Peter Kner
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Article
| Open AccessFast photothermal spatial light modulation for quantitative phase imaging at the nanoscale
Here, the authors present a high-speed photothermal spatial light modulator which can generate a step-like wavefront change without diffraction artifacts. They use this to perform quantitative phase imaging, capturing sub-millisecond motion with a nanometer resolution in 3D.
- Hadrien M. L. Robert
- , Kristýna Holanová
- & Marek Piliarik
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| Open AccessOptical information transmission through complex scattering media with optical-channel-based intensity streaming
Controlling light through disordered scattering media is traditionally done by manipulating optical interference for wavefront shaping. Here, the authors present optical-channel-based intensity streaming, an approach which controls light and transmits information through linear intensity operations.
- Haowen Ruan
- , Jian Xu
- & Changhuei Yang
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Article
| Open AccessLaser scanning reflection-matrix microscopy for aberration-free imaging through intact mouse skull
Microscopic imaging of the brain usually requires thinning of the skull, as it causes complex aberration. Here, the authors introduce a label-free imaging modality termed laser scanning reflection-matrix microscopy, which allows for correcting these aberrations and in vivo imaging through an intact mouse skull.
- Seokchan Yoon
- , Hojun Lee
- & Wonshik Choi
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Article
| Open AccessSnapshot multidimensional photography through active optical mapping
Multidimensional photography has traditionally been restricted by their static optical architectures and measurement schemes. Here, the authors present a tunable multidimensional photography approach employing active optical mapping, which allows them to adapt the acquisition schemes to the scene.
- Jongchan Park
- , Xiaohua Feng
- & Liang Gao
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Article
| Open AccessAn all-photonic focal-plane wavefront sensor
Adaptive optics wavefront sensors need to be in a pupil plane and are insensitive to certain wavefront-error modes. The authors present a wavefront sensor based on a photonic lantern fibre-mode-converter and deep learning, which can be placed at the same focal plane accessing nondegenerate wavefront information and reconstructing the wavefront.
- Barnaby R. M. Norris
- , Jin Wei
- & Sergio G. Leon-Saval
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| Open AccessLabel-free neuroimaging in vivo using synchronous angular scanning microscopy with single-scattering accumulation algorithm
A major challenge of in vivo imaging is imaging deeper, including in turbid tissue. The authors report an adaptive optics based microscope that uses coherent single scattering signal to reduce sample-induced aberrations and enable fast deep-tissue imaging of in vivo larval zebrafish brain.
- Moonseok Kim
- , Yonghyeon Jo
- & Wonshik Choi
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Article
| Open AccessLong-range spatio-temporal correlations in multimode fibers for pulse delivery
Long-range correlations play a role in wave transport through disordered media but have rarely been studied in other systems. Here, the authors discover long-range spatio-temporal correlations in multimode fibers with strong random mode mixing, revealing the possibility of utilizing such correlations for effective pulse delivery through the fiber.
- Wen Xiong
- , Chia Wei Hsu
- & Hui Cao
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Article |
Light focusing in the Anderson regime
Anderson localization is a regime where diffusion is inhibited, leading to the localization of waves. Here, Leonetti et al.use wavefront shaping to achieve focusing in disordered optical fibres in the Anderson regime and demonstrate efficient focusing action.
- Marco Leonetti
- , Salman Karbasi
- & Claudio Conti
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| Open AccessAdaptive real-time dual-comb spectroscopy
The precision of frequency combs makes them the ideal tool for applications in areas such as optical metrology. Here, Ideguchi et al. demonstrate real-time spectroscopy with frequency combs where laser instabilities are electronically compensated, and which is based on commercially available components.
- Takuro Ideguchi
- , Antonin Poisson
- & Theodor W. Hänsch